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性连锁遗传
引用本文:裴开颜. 性连锁遗传[J]. 国际生殖健康/计划生育杂志, 2010, 29(4): 309-311
作者姓名:裴开颜
作者单位:国家人口计生委科学技术研究所,北京,100081
摘    要:
性连锁指性染色体上的基因控制的某些性状伴随性别而遗传的现象。在人类,由于X 染 色体上的基因比Y 染色体上的多,因此X 连锁遗传病较Y连锁遗传病更多见。从医学遗传学角度,对性 连锁遗传病中的X 连锁显性遗传病、X 连锁隐性遗传病和Y 连锁遗传病的遗传特征进行探讨,增加对性 连锁遗传病的认识;通过系谱分析和遗传病再发风险评估,提出相应的医学建议,以期降低性连锁遗传病 的发病率,提高人群遗传素质和出生人口质量。

关 键 词:连锁(遗传学)  X染色体  Y染色体  产前诊断

Sex-Linked Inheritance
PEI Kai-yan. Sex-Linked Inheritance[J]. Journla of International Reproductive Health/Family Planning, 2010, 29(4): 309-311
Authors:PEI Kai-yan
Affiliation:National Research Institute for Family Planning,Beijing 100081,China
Abstract:
Sex linkage is the phenotypic expression of an allele that is related to the chromosomal sex of the individual. In humans, there are many more X-linked traits since there are many more genes on the X than on the Y. This paper highlights the genetic traits of three kinds of sex-linked inherited disease, X- linked dominant inherited disease, X-linked recessive inherited disease and Y-linked inherited disease, from a genetic perspective in order to improve awareness of the sex-linked inherited diseases. The prevalence of some genetic diseases would be reduced, and the population-based hereditary predisposition as well as quality would be improved by evaluation of recurrence risk of a genetic disease and genetic counseling.
Keywords:Linkage(genetics)  X cheromosome  Y chromosome  Prenatal diagnosis  
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