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Transformation of Accessible Chromatin and 3D Nucleome Underlies Lineage Commitment of Early T Cells
Authors:Gangqing Hu  Kairong Cui  Difeng Fang  Satoshi Hirose  Xun Wang  Darawalee Wangsa  Wenfei Jin  Thomas Ried  Pentao Liu  Jinfang Zhu  Ellen V. Rothenberg  Keji Zhao
Affiliation:1. Systems Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA;2. Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA;3. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA;4. Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA;5. Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Abstract:
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  • Keywords:T cell development  lineage commitment  chromatin conformation  4D nucleome  AB compartment conversion  AD connectivity  DNase hypersensitive sites  BCL11B
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