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| 丙酸氟替卡松的合成工艺改进 | |
| 引用本文： | 殷莉梅,韩静,张玥,杨静,潘岳峰. 丙酸氟替卡松的合成工艺改进[J]. 中国药物化学杂志, 2010, 19(1): 29-31,52 |
| 作者姓名： | 殷莉梅 韩静 张玥 杨静 潘岳峰 |
| 作者单位： | 沈阳药科大学 制药工程学院，辽宁 沈阳110016 |
| 摘 要： | 目的 制备丙酸氟替卡松。方法 以醋酸地塞米松为原料，经乙酰化、氟化、水解3步反应制得中间体双氟米松，该中间体再通过氧化、巯基化、酯化、氟甲基化反应制得目标化合物。结果 目标化合物的结构经质谱和核磁共振谱确证，总收率为52.85 ％；高效液相色谱检测含量大于98 ％。结论 由醋酸地塞米松成功地制备丙酸氟替卡松，且有较好的收率和纯度，该工艺路线成本较低，操作简单。 |
| 关 键 词： | 丙酸氟替卡松 醋酸地塞米松 氟米松 制备 |
| 收稿时间： | 2009-04-27 |
| 修稿时间： | 2009-07-20 |
Improved synthesis of fluticasone propionate |
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| YIN Li-mei,HAN Jing,ZHANG Yue,YANG Jing,PAN Yue-feng. Improved synthesis of fluticasone propionate[J]. Chinese Journal of Medicinal Chemistry, 2010, 19(1): 29-31,52 | |
| Authors: | YIN Li-mei HAN Jing ZHANG Yue YANG Jing PAN Yue-feng |
| Affiliation: | YIN Li-mei,HAN Jing,ZHANG Yue,YANG Jing,PAN Yue-feng(School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,China) |
| Abstract: | Aim To synthesize fluticasone propionate.Methods Fluoride betamethasone was prepared from dexamethasone acetate by acetylation,fluorination,hydrolysis.And the target compound was prepared by oxidation,sulfhydrylation,esterification,and fluoromethylation.Results The total yield is 52.85%.The chemical structure of fluticasone propionate was confirmed by MS and 1H-NMR,the content was greater than 98 % ditected by HPLC according to the European Pharmacopia.Conclusion Fluticasone propionate was prepared by dexam... |
| Keywords: | fluticasone propionate dexamethasone acetate flumethasone synthesis |
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