153钐-乙二胺四甲基膦酸联合治疗肺癌骨转移骨痛的疗效观察

目的 探讨153钐-乙二胺四甲基膦酸(153 Sm-EDTMP)核素加伊班膦酸钠(艾本)治疗肺癌骨转移骨痛的疗效.方法 100例肺癌骨转移患者随机分为153Sm-EDTMP加伊班膦酸钠静脉滴注52例(治疗组)、单用153Sm-EDTMP核素治疗组48例(对照组),比较两组止痛效果、活动能力、生活质量改善、溶骨病灶的修复及毒副作用.结果 治疗组疼痛总缓解率为94.2％,明显高于对照组的64.5％(x2=4.78,P＜0.05);治疗组活动能力改善状况的总有效率为82.6％,明显高于对照组的64.5％(x2=4.13,P＜0.05);治疗组生活质量改善状况的总有效率为84.6％,明显高于对照的62.5％(x2 =4.58,P＜0.05);两组毒副作用差异无统计学意义(x2=0.345,P＞0.05).结论 153Sm-EDTMP联合治疗肺癌骨转移,具有止痛、改善活动能力、提高生治质量的疗效.

Effect of 153Sm-EDTMP combined with ibandranate in the treatment of osseous metastasis of lung cancer

Objective To explore the effect of 153Sm-EDTMP combined ibandranate in treatment of osseous metastasis of lung cancer. Methods 100 patients with osseous metastasis of lung cancer were randomly divided into two groups. The patients received intervenous drop infusion of 153Sm-EDTMP and ibandranate in treatment group（ n = 52）. The patients received therapy with 153Sm-EDTMP in control group （n = 48 ）. The differentces of effect of odynoly- sis,locomotor activity,improvement of quality of life, recovery of osteolysis, toxical and adverse reaction between two groups were compared. Results The overall response rate 94.2% in treatment group was significantly higher than that 64.5% in control group （X2 = 4.78, P 〈 0.05 ） ;The activity to improve situation 82.6% in treatment group was signifi candy higher than that 64.5 % in control group （ X2 = 4.13, P 〈 0.05 ） ; The total effective rate of quality of life improve the situation 84.6% in treatment group was significantly higher than that 62.5% in control group（ x2 = 4.58,P 〈 0.05） ;The side effects had no significant difference between two groups （ x2 = 0. 345, P 〉 0.05 ）. Conclusion The treatment of 153 Sm-EDTMP combined with ibandranate in the treatment of osseous-metastasis of lung cancer was effec- tive for relieving pain,improvement locomotor activity,improvement of quality of life, recovery of osteolysis.