结肠癌组织中乳腺癌转移抑制基因1的表达及意义

目的 探讨乳腺癌转移抑制基因1( BRMS1)在结肠癌组织中的表达及其意义.方法 采用免疫组化二步法,检测46例结肠癌组织及癌旁组织中BRMS1蛋白的表达情况,并结合临床病理特征分析其临床意义.结果 结肠癌组织与癌旁组织中BRMS1的阳性表达率分别为34.8％(16/46)、84.8％( 39/46),差异有统计学意义(x2 =23.92,p ＜0.01):BRMS1表达与结肠癌肿块大小、临床分期、淋巴结转移状态密切相关(x2=6.02、4.28、4.35,均P＜O.01),与患者年龄、病理类型等无关.结论 BRMS1在结肠癌的转移过程中可能起到抑制作用,检测结肠癌组织中BRMS1蛋白的表达,有助于判断其预后.

Expression and clinical significance of BRMS1 protein in colon cancer

Objective To investigate the expression and clinical significance of BRMSI （breast cancer me- tastasis suppressorl ） protein in colon cancer. Methods The expression of BRMS1 protein was detected by using EliVision immunohistochemical techniques in 46 cases of colon cancer, and adjacent non cancerous colon tissues. The clinical significance with histopathologic records was aralyzed. Results The expression levels of BRMS1 （34. t~% ） in the colon cancer tissues was significantly lower than those of adjacent non cancerous colon tissues （ X2 = 23.92, P 〈 0. 01 ）. The expression of BRMS1 was significantly correlated with tumor size, clinical stage, and lymph node status （ X2 = 6.02,4.28,4.35, all P 〈 0.01 ） ; BRMS1 had no correlation with age, pathological type. Conclusion BRMS1 might synergistically promote the metastasis of colon cancer. Detection of the expression of BRMS1 may be helpful in determineing the prognosis of colon cancer.