妊娠高血压综合征与25-OH维生素D、血栓烷A_2和前列环素的关系

目的:探讨25-OH维生素D〔25-OHVitD〕对妊娠高血压综合征(妊高征)的影响。方法:采用酶联免疫法测定137例妊高征患者(其中轻度妊高征46例、中度妊高征37例、重度妊高征54例)和72例正常妊娠妇女及70例非孕正常妇女的25-OHVitD含量,同时采用放射免疫法测定血栓烷B2(TXB2)、6-酮-前列腺素F1α(6-keto-PGF1α)含量及TXB2/6-keto-PGF1α比值。结果:正常妊娠组和妊高征各组25-OHVitD、TXB2含量及TXB2/6-keto-PGF1α比值明显高于正常非孕组(P<0·01);妊高征各组25-OHVitD含量明显低于正常妊娠组,而TXB2含量及TXB2/6-keto-PGF1α比值明显高于正常妊娠组(P<0·01),并随着妊高征的加重25-OHVitD含量逐渐下降,TXB2含量及TXB2/6-keto-PGF1α比值随之加大。妊高征3组之间比较,采用方差分析F值分别为21·75、9·21和15·45,具有显著性差异(P<0·01)。结论:妊高征的发生与25-OHVitD含量下降、TXB/6-keto-PGF比值升高有关。

Pregnancy-induced hypertension syndrome and 25-OHVitD,TXA2,PG12 relational discussion

Objective:To study the effect of 25-OHVitD on pregnancy induced hypertension (PIH).Methods:137 women with PIH( including 46 women with mild PIH, 37 women with moderate PIH, 54 women with severe PIH), 72 normal pregnant women and 70 normal women were investigated. The levels of 25-OHVitD were measured by enzyme-linked immunosorbent assay(ELISA), and the levels of TXB2, 6-keto-PGF1α and TXB2/6-keto-PGF1α ratio were measured by radioimmunoassay technique.Results:The levels of 25-OHVitD , TXB2 , TXB2/6-keto-PGF1α were higher in normal pregnant women and PIH group than in normal women group(P<0.01);Serum level of 25-OHVitD in PIH group was lower than in normal pregnant women, but the level of TXB2 and TXB2/6-keto-PGF1α in PIH group were higher than in normal pregnant women(P<0.01). While PIH was more severe, the level of 25-OHVitD was lower, TXB2 and TXB2/6-keto-PGF1α was higher.Comparison between the three groups using chi square, F values were 21.75,9.21 and 15.45,respectively, there was a significant difference (P<0.01) .Conclusion:The occurrence of PIH is related to the decrease of 25 -OHVit D and the increase of TXB2/6-keto-PGF1αratio.