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| 多抗甲素对小鼠巨噬细胞功能的影响 | |
| 引用本文： | 刘晓波 马布仁. 多抗甲素对小鼠巨噬细胞功能的影响[J]. 中国药理学通报, 1994, 10(6): 445-448 |
| 作者姓名： | 刘晓波 马布仁 |
| 作者单位： | 成都军区总医院临床实验研究所 |
| 摘 要： | 对多抗甲素体外影响小鼠腹腔巨噬细胞吞噬中性红染料作用、对Ｌ９２９细胞的细胞毒活性，分泌ＴＮＦ、ＩＬ－１功能等方面进行了探讨。结果表明，ＰＡ能显著增强淀粉刺激的ＭΦ的吞噬功能、细胞毒作用、ＩＬ－１及ＴＮＦ的分泌功能（Ｐ＜０．０５），且呈良好剂量依赖关系。ＰＡ对正常小鼠ＭΦ吞噬功能几乎无明显促进作用（Ｐ＞０．０５），但能明显增强其细胞毒活性（Ｐ＜０．０５）、ＰＡ能协同ＬＰＳ促进ＩＬ－１的分泌（Ｐ＜０．０５），但不能联合ＬＰＳ、ＩＦＮ－ｒ促进ＴＮＦ的分泌（Ｐ＞０．０５）。 |
| 关 键 词： | 多抗甲素；巨噬细胞；吞噬作用；细胞毒；白细胞介素－1；肿瘤坏死因子 |
Effects of polyactin on functions of mice peritoneal macrophages in vitro |
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| LIU Xiao-Bo, MA Bu-Ren, ZENG Xiang-Yuan. Effects of polyactin on functions of mice peritoneal macrophages in vitro[J]. Chinese Pharmacological Bulletin, 1994, 10(6): 445-448 | |
| Authors: | LIU Xiao-Bo MA Bu-Ren ZENG Xiang-Yuan |
| Affiliation: | Clinical Experimental Institute Chengdu Army General Hospital Chengdu 610083 |
| Abstract: | The effects of a novel antitumor antibiotic polyactin (PA) on functions of mice peritoneal macrophages in vitro were investigated. PA could slgnificantly enhance phagocytosis to neutral red particles,cytotoxicity for L929 cells, secreting IL-1, TNF of peritoneal macrophages from starchtreated mice (P<0. 05) dose-dependently.PA could increase the cytotoxicity of normal mice macrophages (P<0.05),but was not effective in their enhancing the phagocytosis (P>0. 05). Synergic promoting effect of PA and lipopolysaccharide (LPS) on secreting IL-1 of macrophages from starch-treated mice was also observed (P<0. 05). |
| Keywords: | polyactinA macrophages phagocytosis cytotoxicity interleukin-1 tumor necrosis factor |
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