|
|||||
|
|
| 小檗碱抗富含血小板血浆凝块收缩的作用及其机制 | |
| 引用本文： | 储钟禄,黄才国,赖福生. 小檗碱抗富含血小板血浆凝块收缩的作用及其机制[J]. 中国药理学通报, 1994, 10(2): 114-116 |
| 作者姓名： | 储钟禄 黄才国 赖福生 |
| 作者单位： | 第二军医大学生化教研室 |
| 摘 要： | 对小檗碱抗富含血小板血浆凝块收缩的作用进行研究，结果表明①小檗碱（ＢＲ）浓度为０．２９～０．８７ｍｍｏｌ·Ｌ－１时．有非常显著的抑制凝块收缩的作用。②ＢＲ浓度为０．５～２．０ｍｍｏｌ·Ｌ－１时．对血小板ｃＡＭＰ水平无影响．提示ＢＲ抑制凝块收缩的作用与ｃＡＭＰ无关．③当外加Ｃａ２＋浓度自０增加到１１．４７ｍｍｏｌ·Ｌ时，凝块收缩率随Ｃａ２＋内流增加而上升。同样条件下．ＢＲ浓度自０增加到０．６ｍｍｏｌ·Ｌ－１时．凝块收缩率显著或非常显著地下降。提示ＢＲ抑制凝块收缩的机制可能是由于直接抑制了Ｃａ２＋内流所致。 |
| 关 键 词： | 小檗碱，富含血小板血浆凝块，凝块收缩作用，血小板，环腺－磷，钙内流 |
The anti-platelet-rich-plasma-clot-retraction effect of berberine and its mechanism |
|
| CHU Zhong-Lu, HUANG Cai-Guo, LAI Fu-Sheng. The anti-platelet-rich-plasma-clot-retraction effect of berberine and its mechanism[J]. Chinese Pharmacological Bulletin, 1994, 10(2): 114-116 | |
| Authors: | CHU Zhong-Lu HUANG Cai-Guo LAI Fu-Sheng |
| Abstract: | The experiments showed that:(1) Berberine(BR),inhibited clot retraction great significantly;( 2) BR had no effect on platelet cAMP level,indicating that there is no relationship between the inhibition of clot retraction by BR and cAMP level; (3) clot retraction gradually increased as the added Ca2 concentration increased. On the same conctition, clot retraction decreased significantly or great significantly as concentration of BR increased.It is indicated that the mechanism of inhibition of clot retraction by BR may be directly due to the inhibition of Ca2 influx. |
| Keywords: | berberine platelet-rich-plasmaclot clot retraction platelet cyclic adenosine monophosphate Ca2 influx |
| 本文献已被 CNKI 等数据库收录！ | |