| 盐酸川芎嗪在大鼠体内的分布 |
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| 引用本文： | 黄志力 桂常青. 盐酸川芎嗪在大鼠体内的分布[J]. 中国药理学通报, 1994, 10(4): 297-300 |
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| 作者姓名： | 黄志力 桂常青 |
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| 作者单位： | 皖南医学院定量药理研究室 |
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| 摘 要： | 观察盐酸川芎嗪（ＴＭＰＨ）３０ｍｇ·ｋｇ－１ｉｖ后大白鼠心、肝、脾、肾、脑、肌肉、睾丸和血浆等组织中药物浓度的经时变化。统计矩分析结果表明：肝脏摄取率最高，ＡＵＣ为２４７．９ｍｇ·ｈ－１·Ｌ－１，其它依次为心脏、脾、脑、睾丸、肺、肾、肌肉、血浆；各组织药物消除的速度依次为：脾、血浆、肌肉、肺、脑、肾、肝、睾丸及心脏，心脏消除最慢，ＭＲＴ为４．２７ｈ。我们认为：药物体内的脏器分布用统计矩法算出的ＡＵＣ、ＭＲＴ，再结合Ｃｍａｘ、Ｔｍａｘ等参数进行描述较为合理。
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| 关 键 词： | 盐酸川芎嗪；体内分布；统计矩；AUC；MRT |
Distribution of tetramethylpyrazine hydrochloride in rats |
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| HUNAG Zhi-Li,GUI Chang-Qing,SUN Rut-Yuan. Distribution of tetramethylpyrazine hydrochloride in rats[J]. Chinese Pharmacological Bulletin, 1994, 10(4): 297-300 |
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| Authors: | HUNAG Zhi-Li GUI Chang-Qing SUN Rut-Yuan |
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| Abstract: | After iv injection of tetramethylpyrazine hydrochloride(TMPH)in rats,the concentration of TMPH in tissues was determined by ultraviolet spectrophotometry. The results showed that concentration of TMPH was highest in liver, followed by heart,spleen,brain,testis,lung,kidney, muscle, plasma. It was suggested that AUC and MRT calculated by moment analysis combined with Cmax and Tmax, were important parameters to evaluate drug distribution. |
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| Keywords: | tetramethylpyrazine hydrochloride distribution statistical moment AUC MRT |
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