Preliminary results of a Japanese nationwide survey of neuroendocrine gastrointestinal tumors |
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| Authors: | Tetsuhide Ito Masao Tanaka Hironobu Sasano Yoshiyuki R. Osamura Iwao Sasaki Wataru Kimura Koji Takano Takao Obara Miyuki Ishibashi Kazuwa Nakao Ryuichiro Doi Akira Shimatsu Toshirou Nishida Izumi Komoto Yukio Hirata Masayuki Imamura Ken Kawabe Kazuhiko Nakamura |
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| Affiliation: | (1) Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan;(2) Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;(3) Department of Pathology, Tohoku University School of Medicine, Sendai, Japan;(4) Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan;(5) Department of Surgery, Tohoku Graduate School of Medicine, Sendai, Japan;(6) Department of Gastroenterological and General Surgery, Course of Organ Functions and Controls, Yamagata University School of Medicine, Yamagata, Japan;(7) Department of Nephrology and Endocrinology, University of Tokyo Faculty of Medicine, Tokyo, Japan;(8) Department of Endocrine Surgery, Tokyo Women's Medical University, Tokyo, Japan;(9) Department of Medicine, Takatsu General Hospital, Kawasaki, Japan;(10) Department of Medicine and Clinical Science, Division of Endocrinology and Metabolism, Kyoto University Graduate School of Medicine, Kyoto, Japan;(11) Department of Surgery, Kyoto University, Kyoto, Japan;(12) Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan;(13) Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan;(14) Department of Surgery, Osaka Saiseikai Noe Hospital, Osaka, Japan;(15) Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan |
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| Abstract: | ![]()
Background We conducted a nationwide survey to estimate the incidence of neuroendocrine gastrointestinal tumors (NETs) newly diagnosed in Japan from 2002 through 2004. Methods Data on 1541 patients, 514 pancreatic endocrine tumors (PETs) and 1027 gastrointestinal carcinoids (GICs), were collected and analyzed. Results Nonfunctioning tumors (NF-PET) constituted 47.7% of PETs. Next in frequency were insulinoma (31.7%) and gastrinoma (8.6%). Malignancy was frequent in NF-PETs (46.1%) and gastrinomas (45.5%), but only 7.4% of insulinomas were malignant. The incidence of multiple endocrine neoplasia type-1 associated with PETs was 7.4%. The incidence of GICs was 28.8%, 5.2%, and 66.0% in foregut, midgut, and hindgut, respectively. Carcinoid syndrome and metastases were observed in only 1.7% and 5.6% of GICs, respectively. Conclusions The incidence of NETs in Japan was clarified by this preliminary study. Comparatively large differences in GICs between Japan and Western nations were present with regard to the location, symptomatic status, and prevalence of malignancy. |
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| Keywords: | neuroendocrine tumor endocrine pancreatic tumor gastrointestinal carcinoid nationwide survey |
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