川崎病患儿血清白细胞介素-6、-10、-1水平变化及意义

目的 观察川崎病患儿血清白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、白细胞介素-1(IL-1)水平变化及其临床意义.方法 选取38例川崎病患儿(观察组)和38例健康儿童(对照组)血清IL-6、IL-10和IL-1水平,观察两组差异及对治疗效果的影响.结果 观察组IL-6、IL-10和IL-1水平均高于对照组(t=10.3877、15.1010、15.1243,均P＜0.05),观察组急性期IL-6、IL-10、IL-1等水平明显高于亚急性期患儿(t=9.7594、11.6486、11.6622,均P＜0.05)及对照组(t=11.7032、11.7718、11.8267,均P＜0.05).对照组48 h内细胞凋亡率为(2.8±0.8)％,明显低于川崎病患儿的(38.3±7.9)％(t=38.59,P＜0.01).血小板升高[(464.0±110.2)×109/L]的川崎病患儿IL-1水平(663±94) ng/L,明显高于无血小板升高[(307.0±104.9)×109/L]的患儿(492±92) ng/L(t =13.1044,P＜0.05).结论 检测川崎病患儿血清IL-6、IL-10和IL-1水平,有助于临床判断的病情、并发症情况及治疗效果,具有重要的临床意义.

Changes of serum IL-6, IL-10 and IL-1 in patients with Kawasaki disease and its clinical significance

Objective To observe the serum levels of IL-6,IL-10 and IL-1 in children with Kawasaki disease and its clinical significance. Methods 38 childrey with of Kawasaki disease were selected as observction group,then selected 38 cases of normal children as control group. Serum IL-6, IL-10 and IL-1 levels were observed two groups. Results Observation group IL-6, IL-10 and IL-1 levels were higher（t = 10. 3877,15. 1010,15. 1243, all P 〈 0.05）, acute phase of observation group IL-6, IL-10, IL-1, etc. levels were significantly higher than the sub-acute phase patients （t = 9. 7594,11. 6486,11. 6622, all P 〈 0.05 ） and control group （ t = 11. 7032,11. 7718,11. 8267, all P 〈 0. 05 ）. 48h apoptosis rate in the control group（2.8 ± 0.8 ） % was significantly lower than in children with Kawasaki disease（38.3 ±7.9）% （t =38.59,P 〈0.01 ）. Platelets increased[ （464.0 ± 110.2）×10^9/L] of the IL-1 level in children with Kawasaki disease （663 ± 94）ng/L was significantly higher than those without elevated platelet [ （307.0 ±104.9） ×10^9/L ] of children （592 ±92） ng/L（ t = 13. 1044, P 〈 0.05 ）. Conclusion The detection of serum IL-6, IL- 10 and IL-1 levels may aid clinical diagnosis of the condition of children with Kawasaki disease, complications and treatment, have important clinical significance.