慢性阻塞性肺疾病分级与血清白蛋白水平相关性研究

目的 了解慢性阻塞性肺疾病(COPD)患者血清白蛋白水平与病情严重度分级的相关性.方法 120例COPD患者按病情严重度分级分为Ⅰ、Ⅱ、Ⅲ、Ⅳ四级,收集患者空腹血清白蛋白,采用微型营养评定表(MNA)、体质量指数(BMI)、血清白蛋白3个营养指标分别对患者进行营养评定,并分析比较.结果 Ⅰ级COPD患者营养良好者、轻度营养不良者和低白蛋白血症者人数分别为34例、6例、1例,Ⅱ级分别为8例、9例、2例,Ⅲ级分别为18例、12例、4例,Ⅳ级分别为7例、13例、6例,营养不良发生率分别为17.1％、57.9％、47.1％和73.1％；COPD严重度分级与血清白蛋白的相关指数为0.251 (P ＜0.05)；COPD患者Ⅰ级与Ⅱ、Ⅲ、Ⅳ级间血清白蛋白的相关指数分别为0.273、0.331、0.324(均P＜0.05).结论 COPD严重度分级与血清白蛋白的下降具有相关性,随COPD级别增加血清白蛋白下降越明显.

Correlated study between chronic obstructive pulmonary disease classification and serum albumin level

Objective To explore serum albumin level of the patients with chronic obstructive pulmonary disease （COPD） and disease severity grading of the relationship between the early, better, a reasonable nutritional support in patients with COPD. Methods 120 COPD patients were randomly divided into four levels according to the disease severity, Ⅰ level as the control group,Ⅱ、Ⅲ、Ⅳ grade for the experimental group, collectting fasting serum albumin, micro-nutrition assessment form （ MNA ）, body mass index （ BMI）, serum albumin, three nutrition indicators were assessed in patients with COPD, the control group data were compared with the three experimental groups. ResultsⅠ level of COPD were well-nourished patients, mild malnutrition and hypoalbuminemia were 34,6,1 respectively. Ⅱ level were 8,9,2, In level were 18,12,4, Ⅳ level were 7,13,6. Malnutrition rates were 17. 1%, 57.9% ,47.1% and 73.1% ,COPD associated with serum albumin level index was 0.251 （P 〈0.05） ;COPD patients with grade Ⅰ and Ⅱ、Ⅲ、Ⅳ level of serum white protein-related indices were 0. 273 , 0. 331, 0. 324 （ all P 〈 0.05）. Conclusion COPD severity grading and the decline in serum albumin were correlated, the serum albumin level decreased more significantly.