| 褪黑素对小鼠反复脑缺血再灌注损伤学习记忆的改善作用及机制 |
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| 引用本文： | 霍展样,刘东华,刘晓丽.褪黑素对小鼠反复脑缺血再灌注损伤学习记忆的改善作用及机制[J].中国临床药理学与治疗学,2003,8(5):567-569. |
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| 作者姓名： | 霍展样 刘东华 刘晓丽 |
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| 作者单位： | 1. 新乡医学院机能学实验室,新乡,453003,河南
2. 新乡医学院物理教研室,新乡,453003,河南 |
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| 摘 要： | 目的：研究褪黑素(melatonin，MT)对反复脑缺血再灌注损伤的保护作用及机制。方法：采用清醒小鼠造成反复脑缺血再灌注损伤模型，应用电迷宫法观察小鼠学习记忆情况，比色法、硝酸还原法检测脑组织丙二醛(MDA)、一氧化氮(NO)含量。结果：褪黑素可以明显改善反复脑缺血再灌注小鼠的学习记忆能力，同时可不同程度地抑制脑水肿及由反复脑缺血再灌注引起的脑组织中异常升高的MDA、NO含量。结论：MT对反复脑缺血再灌注损伤有显的保护作用，其机制可能与抑制脑水肿及抑制脑内升高的MDA、NO有关。
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| 关 键 词： | 药理学 脑缺血再灌注 褪黑素 学习与记忆 丙二醛 一氧化氮 |
| 文章编号： | 1009-2501(2003)04-0567-03 |
| 修稿时间： | 2003年2月24日 |
Improved effect of melatonin on learning and memory in mice with repeated cerebral ischemia and reperfusion and its mechanism |
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| HUO Zhan Yang,LIU Dong Hua ,LIU Xiao Li Functional Laboratory.Improved effect of melatonin on learning and memory in mice with repeated cerebral ischemia and reperfusion and its mechanism[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2003,8(5):567-569. |
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| Authors: | HUO Zhan Yang LIU Dong Hua LIU Xiao Li Functional Laboratory |
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| Institution: | HUO Zhan Yang,LIU Dong Hua 1,LIU Xiao Li Functional Laboratory,1 Department of Physical,Xinxiang Medical College,Xinxiang 453003,Henan,China |
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| Abstract: | AIM: To study the protective effect and mechanism of melatonin on learning and memory in mice with repeated cerebral ischemia and reperfusion and its mechanism. METHODS: The models of repeated cerebral ischemia reperfusion were established in mice. The function of learning and memory was tested by the electric mare method, and the concentrations of MDA and NO were measured by colorimetric method and nitric reduction method in brain tissue. RESULTS: MT could obviously improve the function of learning and memory of model mice, inhibit cerebral dropsy, and lower the content of MDA and NO in cerebral tissue. CONCLUSION: MT shows significantly protective effect against repeated ischemia reperfusion injury in mice, and the mechanism might be related to inhibit the rise of MDA and NO in brain tissue. |
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| Keywords: | pharmacology melotonin cerebral ischemia reperfusion malonydialdehyde nitrogen monoxide |
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