| 自体肺体外循环与常规体外循环对细胞因子影响的实验对比研究 |
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| 引用本文： | 林柏松,张秀和,张柏民,姜亦忠,李哲. 自体肺体外循环与常规体外循环对细胞因子影响的实验对比研究[J]. 中国免疫学杂志, 2010, 26(3) |
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| 作者姓名： | 林柏松 张秀和 张柏民 姜亦忠 李哲 |
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| 作者单位： | 吉林大学中日联谊医院心脏外科,长春,130033 |
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| 基金项目： | 吉林省科技厅科技发展计划基金资助课题 |
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| 摘 要： | 目的:探讨以自体肺取代人工肺的体外循环方法对犬体外循环相关性炎症反应的影响。方法:将12只杂种犬随机分为对照组及实验组(每组6只)。对照组在体外循环(CPB)期间使用膜式氧合器,实验组在CPB期间使用自体肺进行氧合,两组均阻断主动脉90分钟、辅助循环30分钟,于CPB前(T1)、转流后60分钟(T2)、停机后60分钟(T3)、停机后120分钟(T4)抽取动脉血,测定血浆肿瘤坏死因子α(TNFα-)、白细胞介素6(IL-6)、白细胞介素8(IL-8)和白细胞介素10(IL-10)浓度。结果:两组实验犬血浆TNFα-、IL-6、IL-8和IL-10的浓度,在T2~T4各时点与体外循环前比较均明显增加(P0.01);T2~T4时点实验组血浆TNFα-、IL-6和IL-8浓度明显低于对照组(P0.01),IL-10浓度明显高于对照组(P0.05)。结论:自体肺体外循环可抑制体外循环过程中促炎细胞因子TNFα-、IL-6和IL-8的释放,促进抗炎细胞因子IL-10的释放,从而减轻常规体外循环引起的全身炎症反应。
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| 关 键 词： | 自体肺 炎症反应 细胞因子 体外循环 |
The empirical study for the effect of extracorporeal circulation with autologous lung and conventional extracorporeal circulation as oxygenator on cytokine levels |
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| LIN Bai-Song,ZHANG Xiu-He,ZHANG Bai-Min,JIANG Yi-Zhong,LI Zhe. The empirical study for the effect of extracorporeal circulation with autologous lung and conventional extracorporeal circulation as oxygenator on cytokine levels[J]. Chinese Journal of Immunology, 2010, 26(3) |
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| Authors: | LIN Bai-Song ZHANG Xiu-He ZHANG Bai-Min JIANG Yi-Zhong LI Zhe |
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| Affiliation: | LIN Bai-Song,ZHANG Xiu-He,ZHANG Bai-Min,JIANG Yi-Zhong,LI Zhe.Department of Cardiovascular Surgery,China-Japan Union Hospital,Jilin University,Changchun 130033,China |
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| Abstract: | Objective:To determine the protective effect of cardio-pulmonary bypass(CPB) with autologous lung as oxygenator on CPB-relative inflammatory response.Methods:Twelve adult mongrel dogs were randomly divided into control group and study group.Cardiopulmonary bypass(CPB) using a membrane oxygenator(control group) or using the autologous lung(study group) for gas exchange was performed for 120 min in an alternating series of 12 mongrel dogs with the heart arrested for 90 min by crystalloid cardioplegia and 30 m... |
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| Keywords: | Autologous lung Inflammatory response Cytokine Cardiopulmonary bypass |
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