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| 安徽、河南、山西3省自愿咨询检测人群HIV/HCV共感染及HCV基因亚型初步分析 | |
| 引用本文： | 赵晶,潘品良,王哲,乔晓春,苏斌,肖瑶,蒋岩. 安徽、河南、山西3省自愿咨询检测人群HIV/HCV共感染及HCV基因亚型初步分析[J]. 中国输血杂志, 2009, 22(5) |
| 作者姓名： | 赵晶 潘品良 王哲 乔晓春 苏斌 肖瑶 蒋岩 |
| 作者单位： | 1. 中国疾病预防控制中心,性病艾滋病预防控制中心,国家艾滋病参比实验室,北京,100050 2. 河南省疾病预防控制中心 3. 山西省疾病预防控制中心 4. 安徽省疾病预防控制中心 |
| 摘 要： | 目的了解目前我国安徽、河南、山西3省自愿咨询检测(VCT)人群HIV感染者中HIV/HCV共感染率及HCV亚型的分布情况。方法对来自安徽、河南、山西3省VCT人群中HIV阳性样本进行HCV抗体检测并对HCV阳性的样本进行HCVC/E1区RT-PCR扩增、基因测序,分析HCV的亚型分布。结果在HIV阳性的382份样本中,检出HCV阳性215份,3省VCT人群HIV感染者中HIV/HCV共感染率平均为56.3%,安徽、河南、山西3省分别为50.0%、59.3%、42.9%。其中,经血传播人群的HIV/HCV共感染率为72.1%,经性传播人群为33.3%,其它途径人群为36.6%。HCV PCR扩增成功98份,1b亚型69份(70%),2a亚型28份(29%),3a亚型1份(1%)。结论安徽、河南、山西VCT人群具有较高的HIV/HCV共感染率;经性传播人群HIV/HCV共感染率高于国外水平;HIV/HCV共感染对HCV亚型分布无显著影响。 |
| 关 键 词： | HIV HCV HIV/HCV共感染 基因亚型 |
Study on HIV/HCV co-infection and genotyping of HCV in three provinces of China |
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| ZHAO Jing,PAN Pinliang,WANG Zhe,et al.. Study on HIV/HCV co-infection and genotyping of HCV in three provinces of China[J]. Chinese Journal of Blood Transfusion, 2009, 22(5) | |
| Authors: | ZHAO Jing PAN Pinliang WANG Zhe et al. |
| Affiliation: | ZHAO Jing1,PAN Pinliang1,WANG Zhe2,et al. 1National AIDS Reference Laboratory,National Center for AIDS/STD Control , Prevention,China CDC,Beijing 10000,China,2. Henan Center for Disease Control , Prevention |
| Abstract: | Objective To investigate the prevalence rate of HIV/HCV co-infection in Anhui, Henan and Shanxi provinces, and to explore the genotypes of HCV in HIV/HCV co-infected samples. Methods HCV antibody was detected by using enzyme immunoassay for HIV positive samples of VCT people. RT-PCR was used to amplify C/E1region of HCV. Genotypes of HCV were determined by genetic characterization of viral sequences. Results The HCV co-infection rate in Anhui, Henan, Shanxi provinces was 56.3% on average, and the rate in ea... |
| Keywords: | HIV HCV HIV/HCV co-infection Genotype |
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