Columnar Cell Carcinoma of the Thyroid: MIB-1 Immunoreactivity as a Prognostic Factor |
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| Authors: | Hirokawa Mitsuyoshi Shimizu Michio Fukuya Takashi Manabe Toshiaki Sonoo Hiroshi |
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| Affiliation: | (1) Department of Breast and Thyroid Surgery, Kawasaki Medical School, Kurashiki, Okayama, Japan;(2) Department of Pathology, Kawasaki Medical School, 577 Matsushima, 01-01 Kurashiki-City, Okayama, Japan |
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| Abstract: | ![]()
We report a case of columnar cell carcinoma of the thyroid. A 47-year-old Japanese man had a nonencapsulated thyroid mass that infiltrated the surrounding tissues extensively. Seventeen months after thyroidectomy he died of respiratory failure resulting from tracheal invasion. An autopsy showed distant metastases to the liver, lung, esophagus, and pancreas. Histologically, the thyroid mass consisted of tall columnar atypical cells with marked nuclear stratification. About one-fifth of tumor cells were immunopositive for MIB-1. The MIB-1 positive index of our case was extremely high, compared with that of ordinary papillary carcinoma. This case indicates that biological growth activity in columnar cell carcinoma may be similar to that of undiferentiated carcinoma of the thyroid, since the MIB-1-positive index is close to each other. |
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| Keywords: | Thyroid columnar cell carcinoma papillary carcinoma poorly differentiated carcinoma MIB-1 |
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