| 不同促渗剂对黄芩苷离体鼠皮透过行为的影响 |
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| 引用本文： | 赵诤,宋西卫,刘志东. 不同促渗剂对黄芩苷离体鼠皮透过行为的影响[J]. 天津中医药, 2009, 26(5): 423-425 |
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| 作者姓名： | 赵诤 宋西卫 刘志东 |
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| 作者单位： | 天津中医药大学中医药研究院,天津,300193;天津中医药大学现代中药发现与制剂技术教育部工程研究中心,天津,300193 |
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| 基金项目： | 国际科技合作计划项目，国家科技支撑计划项目 |
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| 摘 要： | [目的]研究辛酸/癸酸甘油酯(Lab)、二乙二醇单乙基醚(Trans P)以及丙二醇(PG)对黄芩苷透皮行为的影响.[方法]采用改良Franz扩散池,考察Lab、Trans P和PG在不同浓度下,对黄芩苷离体鼠皮透过行为的影响.[结果]与空白组相比,3%Trans P与5%PG的表观渗透系数增加了3.15和3.05倍,有差异(P＜0.05),几种促渗剂对黄芩苷透过的增渗作用依次为3%Trans P＞5%PG＞7%PG＞5%Trans P＞7%Trans P＞3%PG＞1%Trans P＞10%PG＞5%Lab.[结论] 3%Trans P与5%PG的促渗效果比较明显,可进一步应用于黄芩苷透皮制剂中.
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| 关 键 词： | 促渗剂 黄芩苷 影响 |
| 收稿时间： | 2009-04-11 |
The effects of different penetration enhancers on transdermal behavior of Baicalin in rat in vitro |
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| ZHAO Zheng,SONG Xi-wei and LIU Zhi-dong. The effects of different penetration enhancers on transdermal behavior of Baicalin in rat in vitro[J]. Tianjin Journal of Traditional Chin Medicine, 2009, 26(5): 423-425 |
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| Authors: | ZHAO Zheng SONG Xi-wei LIU Zhi-dong |
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| Affiliation: | Tianjin University of TCM, Research institute of Traditional Chinese Medicine, Tianjin, China;Tianjin University of TCM, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin, 300193, China;Tianjin University of TCM, Research institute of Traditional Chinese Medicine, Tianjin, China;Tianjin University of TCM, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin, 300193, China;Tianjin University of TCM, Research institute of Traditional Chinese Medicine, Tianjin, China;Tianjin University of TCM, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin, 300193, China |
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| Abstract: | [Objective] To study the effects of Lab,Trans P and PG on the transdermal behavior of Baicalin in rat. [Methods] The Franz modified diffusion chamber was applied for evaluating the effect of different concentrations of each penetration enhancer (PE) on the permeability of Baicalin in vitro. [Results] Compared with control (P<0.05),3% Trans P and 5% PG could increase the apparent permeability as much as 3.15 and 3.05 folds. The penetration rate with the PE:3%Trans P>5%PG>7%PG>5%TransP>7%TransP>3%PG>1% TransP>10%PG>5%Lab. [Conclusion] The enhance effect of 3%TransP and 5%PG is significant,and is likely to apply in the further re-search. |
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| Keywords: | penetration enhancer Baicalin |
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