| 肝纤维化发病机制与临床诊断的研究进展 |
| |
| 引用本文： | 邵祥强,肖华胜. 肝纤维化发病机制与临床诊断的研究进展[J]. 世界华人消化杂志, 2011, 0(3): 268-274 |
| |
| 作者姓名： | 邵祥强 肖华胜 |
| |
| 作者单位： | 中国科学院上海生命科学研究院系统生物学重点实验室功能基因组;中国科学研究生院;生物芯片上海国家工程研究中心; |
| |
| 基金项目： | 国家高技术研究发展计划(863)基金资助项目,No.2006AA02A411~~ |
| |
| 摘 要： | 肝纤维化是机体对各种病因引起的慢性肝损伤后的一种损伤修复反应,慢性肝病发展至最后将发展成为肝硬化,肝硬化及其并发症威胁着全球居民的生命健康.在过去的几十年中,人们在肝纤维化的发生机制方面已经取得了很大的进展.HSC的激活是肝纤维化发生过程中的一个重要事件,同时各类细胞因子与其对应受体;以及各类炎症细胞均在纤维化发展过程...
|
| 关 键 词： | 肝纤维化 肝星状细胞 纤维化发生 诊断 肝活检 血清学标志物 |
Liver fibrosis: pathogenesis and clinical diagnosis |
| |
| Xiang-Qiang Shao,Center for Functional Genomics,Key Laboratory of Systems Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Graduate School of the Chinese Academy of Sciences,Shanghai ,China Hua-Sheng Xiao,National Engineering Center for Biochip at Shanghai,Shanghai ,China. Liver fibrosis: pathogenesis and clinical diagnosis[J]. World Chinese Journal of Digestology, 2011, 0(3): 268-274 |
| |
| Authors: | Xiang-Qiang Shao Center for Functional Genomics Key Laboratory of Systems Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of Sciences Shanghai China Hua-Sheng Xiao National Engineering Center for Biochip at Shanghai Shanghai China |
| |
| Affiliation: | Xiang-Qiang Shao,Center for Functional Genomics,Key Laboratory of Systems Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Graduate School of the Chinese Academy of Sciences,Shanghai 200031,China Hua-Sheng Xiao,National Engineering Center for Biochip at Shanghai,Shanghai 201203,China |
| |
| Abstract: | Hepatic fibrosis represents a wound healing response to liver injury due to various causes. Cirrhosis is the most advanced stage of fibrosis and, along with its complications, constitutes one of the major causes of morbidity and mortality worldwide. Past decades have witnessed tremendous progress in understanding the mechanisms of hepatic fibrosis. Activation of hepatic stellate cells is a key event in fibrosis, while a wide range of cytokines and their receptors and inflammatory cell subsets participate in... |
| |
| Keywords: | Liver fibrosis Hepatic stellate cells Fibrogenesis Diagnosis Liver biopsy Serum biomarker |
| 本文献已被 CNKI 等数据库收录！ |
|
