| 姜辣素辅助昂丹司琼对顺铂所致大鼠异嗜行为的抑制作用 |
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| 引用本文： | 杨玉玲,岳旺,田字彬,王茂龙,杨志宏,张琪,魏良洲,赵清喜,石振艳. 姜辣素辅助昂丹司琼对顺铂所致大鼠异嗜行为的抑制作用[J]. 世界华人消化杂志, 2011, 0(10): 1034-1039 |
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| 作者姓名： | 杨玉玲 岳旺 田字彬 王茂龙 杨志宏 张琪 魏良洲 赵清喜 石振艳 |
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| 作者单位： | 青岛大学医学院附属医院消化内科;青岛大学医学院药学系;青岛大学医学院附属医院胸外科; |
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| 基金项目： | 国家自然科学基金资助项目,No.30873108/H3108; 山东省自然基金资助项目,No.Y2007C097~~ |
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| 摘 要： | 目的:研究姜辣素辅助昂丹司琼对顺铂所致大鼠急性期和延迟期异嗜行为的抑制作用.方法:大鼠随机分成正常对照组、模型组、昂丹司琼组、姜辣素组及姜辣素+昂丹司琼组,记录顺铂注射后0-24 h和48-72 h各组大鼠摄食量及啃食高岭土量.72 h后取延髓极后区及近端空肠组织,免疫组织化学方法测定组织中P物质表达.结果:顺铂注射后...
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| 关 键 词： | 姜辣素 P物质 异嗜 化疗性呕吐 |
Ondansetron in combination with gingerol suppresses cisplatin-induced pica in rats |
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| Yu-Ling Yang,Zi-Bin Tian,Qi Zhang,Liang-Zhou Wei,Qing-Xi Zhao. Ondansetron in combination with gingerol suppresses cisplatin-induced pica in rats[J]. World Chinese Journal of Digestology, 2011, 0(10): 1034-1039 |
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| Authors: | Yu-Ling Yang Zi-Bin Tian Qi Zhang Liang-Zhou Wei Qing-Xi Zhao |
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| Affiliation: | Yu-Ling Yang,Zi-Bin Tian,Qi Zhang,Liang-Zhou Wei,Qing-Xi Zhao,Department of Gastroenterology,Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,Shandong Province,China Wang Yue,Zhi-Hong Yang,Zhen-Yan Shi,Department of Pharmacy,Qingdao University Medical College,Qingdao 266021,China Mao-Long Wang,Department of Thoracic Surgery,China |
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| Abstract: | AIM:To investigate whether ondansetron in combination with gingerol has suppressive effect on cisplatin-induced acute and delayed pica behavior in rats.METHODS:Rats were divided randomly into blank control group,model control group,ondansetron group,gingerol group,and ondan-setron plus gingerol group.Kaolin and food ingestion were recorded during 0-24 h and 48-72 h after cisplatin administration.At 72 h,the area postrema and jejunum tissue samples were taken to detect the immunoexpression of substance P by ... |
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| Keywords: | Gingerol Substance P Pica Vomiting Chemotherapy-induced nausea and vomiting |
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