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| 乙型肝炎病毒基因型 | |
| 引用本文： | 陈秀丽,孙殿兴,张晓岚. 乙型肝炎病毒基因型[J]. 世界华人消化杂志, 2011, 0(4) |
| 作者姓名： | 陈秀丽 孙殿兴 张晓岚 |
| 作者单位： | 中国人民解放军白求恩国际和平医院;河北医科大学第二医院消化科河北省消化病重点实验室河北省消化病研究所; |
| 基金项目： | 国家“十一五”“艾滋病和病毒性肝炎等重大传染病防治”重大专项基金资助项目,No.2008ZX10002-011~~ |
| 摘 要： | 乙型肝炎病毒(hepatitis B virus,HBV)是嗜肝DNA病毒家族的重要成员,所引起的慢性乙型病毒性肝炎及肝衰竭、肝硬化、肝癌等是严重危害人民健康的疾病.据统计,目前我国有慢性乙型肝炎患者2000万人,是我国现阶段最为突出的公共卫生问题之一.HBV遗传变异率很高,有8个基因型,由于独特的流行病学特性,多数又可以分为不同的基因亚型.另外DNA基因型的高度异质性使重组基因型也增加了.有研究证实HBV基因型与疾病进展关系密切.不同基因型HBV的流行病学特征不同,同时其临床感染特点和致病性也有差异.本文综述了本领域研究进展,包括HBV生物学特性、基因型与基因亚型、重组基因型、HBV基因型的流行病学特点以及HBV基因型与临床等方面. |
| 关 键 词： | 人嗜肝DNA病毒属 禽嗜肝DNA病毒属 乙型肝炎病毒 基因型 基因亚型 重组基因型 |
Hepatitis B virus genotypes |
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| Xiu-Li Chen,Dian-Xing Sun,Bethune International Peace Hospital of Chinese PLA,Shijiazhuang ,Hebei Province,China Xiu-Li Chen,Xiao-Lan Zhang. Hepatitis B virus genotypes[J]. World Chinese Journal of Digestology, 2011, 0(4) | |
| Authors: | Xiu-Li Chen Dian-Xing Sun Bethune International Peace Hospital of Chinese PLA Shijiazhuang Hebei Province China Xiu-Li Chen Xiao-Lan Zhang |
| Affiliation: | Xiu-Li Chen,Dian-Xing Sun,Bethune International Peace Hospital of Chinese PLA,Shijiazhuang 050082,Hebei Province,China Xiu-Li Chen,Xiao-Lan Zhang,Department of Gastroenterology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China |
| Abstract: | Hepatitis B virus(HBV) is a member of the hepadnavirus family and can lead to severe liver disease.HBV has a very high genetic variability.Currently,eight genotypes of HBV have been recognized,and most genotypes are now divided into subgenotypes with distinct virological and epidemiological properties.In addition,recombination among HBV genotypes increases the variability of HBV.This review summarizes current knowledge of the epidemiology of genetic variability in hepadnaviruses and,due to rapid progress in... |
| Keywords: | Orthohepadnavirus Avihepdnavirus Hepatitis B virus Genotype Subgenotype Recombinant genotype |
| 本文献已被 CNKI 等数据库收录！ | |