| 姜黄素对DSS诱导的小鼠溃疡性结肠炎的疗效 |
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| 引用本文： | 陈欧,李昌平,罗彬,冯琦,马春华,冯凯祥. 姜黄素对DSS诱导的小鼠溃疡性结肠炎的疗效[J]. 世界华人消化杂志, 2011, 0(7): 680-686 |
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| 作者姓名： | 陈欧 李昌平 罗彬 冯琦 马春华 冯凯祥 |
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| 作者单位： | 四川省泸州医学院附属医院;四川省绵阳市中心医院; |
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| 摘 要： | 目的:观察姜黄素对葡聚糖硫酸钠(DSS)诱导的小鼠溃疡性结肠炎的疗效,并探讨其作用机制.方法:选♀BALB/c小鼠60只,随机分为4组,每组15只.A组:正常对照组:B组:DSS结肠炎组,小鼠每日自由摄取5%DSS溶液:C组:姜黄素治疗组,小鼠自由摄取5%DSS溶液,每日腹腔注射姜黄素悬液30 mg/kg;D组:地塞米...
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| 关 键 词： | 姜黄素 葡聚糖硫酸钠 溃疡性结肠炎 核因子κB |
Eff icacy of curcumin in the management of dextran sulphate sodium-induced ulcerative colitis in mice |
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| Ou Chen,Chang-Ping Li,Bin Luo. Eff icacy of curcumin in the management of dextran sulphate sodium-induced ulcerative colitis in mice[J]. World Chinese Journal of Digestology, 2011, 0(7): 680-686 |
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| Authors: | Ou Chen Chang-Ping Li Bin Luo |
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| Affiliation: | Ou Chen,Chang-Ping Li,Bin Luo,Department of Gastroenterology,the Affiliated Hospital of Luzhou Medical College,Luzhou 646000,Sichuan Province,China Qi Feng,Chun-Hua Ma,Kai-Xiang Feng,Mianyang Central Hospital,Mianyang,621000,China |
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| Abstract: | AIM:To investigate the efficacy of curcumin in the treatment of dextran sulphate sodium(DSS)induced ulcerative colitis in mice.METHODS:Sixty female BALB/c mice were randomly divided into four groups:normal group,experimental colitis group(administered with 5% DSS solution),curcumin treatment group(administered with 5% DSS solution and intraperitoneally injected with curcumin,30 mg/kg body weight),dexamethasone treatment group(administered with 5% DSS solution and intraperitoneally injected with dexamethason... |
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