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| 己酮可可碱对重度失血性休克大鼠再灌注后肝损伤的影响 | |
| 引用本文： | 陆化梅,耿智隆,赵峰,杨木强. 己酮可可碱对重度失血性休克大鼠再灌注后肝损伤的影响[J]. 世界华人消化杂志, 2011, 0(3): 227-232 |
| 作者姓名： | 陆化梅 耿智隆 赵峰 杨木强 |
| 作者单位： | 兰州大学第二临床医学院麻醉系;中国人民解放军兰州军区兰州总医院麻醉科; |
| 基金项目： | 全军“十一五”面上基金资助项目,No.06MA083~~ |
| 摘 要： | 目的:研究已酮可可碱(PTX)对重度失血性休克大鼠再灌注后肝损伤的影响,并探讨其可能的作用机制.方法:48只SD大鼠随机分为4组:对照组(C组)、单纯体克组(NR组)、乳酸林格氏液组(LR组)、乳酸林格氏液联合PTX组(LRPTX组).复制重度失血性休克模型,连续检测MAP的变化.LR及LRPTX组以3倍失血量LR/L... |
| 关 键 词： | 失血性休克 肝损伤 复苏 己酮可可碱 |
Treatment with pentoxifylline reduces ischemia/reperfusion-induced liver injury in rats with severe hemorrhagic shock |
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| Hua-Mei Lu. Treatment with pentoxifylline reduces ischemia/reperfusion-induced liver injury in rats with severe hemorrhagic shock[J]. World Chinese Journal of Digestology, 2011, 0(3): 227-232 | |
| Authors: | Hua-Mei Lu |
| Affiliation: | Hua-Mei Lu,Department of Anesthesia,the Second Clinical Medical College of Lanzhou University,Lanzhou 730050,Gansu Province,China Zhi-Long Geng,Feng Zhao,Mu-Qiang Yang,Department of Anesthesiology,Lanzhou General Hospital of Chinese PLA Lanzhou Military Command,China |
| Abstract: | AIM: To investigate the effects of treatment with pentoxifylline (PTX) on ischemia/reperfusioninduced liver injury in rats with severe hemorrhagic shock. METHODS: Forty-eight Sprague-Dawley rats were randomly and equally divided into four groups: control group, shock group (NR group), Lactated Ringer's (LR) solution-treated group (LR group), LR solution plus PTX group (LRPTX group). A rat model of severe hemorrhagic shock was generated, and arterial blood pressure (MAP) was determined continuously. Blood sp... |
| Keywords: | Hemorrhagic shock Liver injury Resuscitation Pentoxifylline |
| 本文献已被 CNKI 等数据库收录！ | |