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| PTEN在胃癌中的研究进展 | |
| 引用本文： | 杨桢,吕农华. PTEN在胃癌中的研究进展[J]. 世界华人消化杂志, 2011, 0(6): 608-613 |
| 作者姓名： | 杨桢 吕农华 |
| 作者单位： | 南昌大学第一附属医院消化内科江西省消化系疾病研究所江西省消化病研究重点实验室; |
| 基金项目： | 国家自然科学基金资助项目,No. 81060038; 江西省研究生创新专项资金资助项目,No. YC10A020~~ |
| 摘 要： | 第10号染色体同源缺失性磷酸酶-张力蛋白基因(phosphatase and tensin homolog deleted on chromosome ten,PTEN)是继p533之后发现的另一重要的抑癌基因,其编码的蛋白质可调控多种细胞信号转导通路或功能分子,构成一个复杂的网络系统,在调控细胞增殖与凋亡、迁移与黏附... |
| 关 键 词： | 第10号染色体同源缺失性磷酸酶-张力蛋白基因 胃癌 致癌机制 |
Role of PTEN in gastric carcinogenesis |
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| Zhen Yang,Nong-Hua Lv. Role of PTEN in gastric carcinogenesis[J]. World Chinese Journal of Digestology, 2011, 0(6): 608-613 | |
| Authors: | Zhen Yang Nong-Hua Lv |
| Affiliation: | Zhen Yang,Nong-Hua Lv,Department of Gastroenterology,the First Affiliated Hospital of Nanchang University,Gastroenterology Institute of Jiangxi Province,Jiangxi Provincial Key Laboratory for Digestive Diseases,Nanchang 330006,Jiangxi Province,China |
| Abstract: | The PTEN(phosphatase and tensin homolog deleted on chromosome ten) gene is another important tumor suppressor gene found after p53 gene,and its encoded protein is involved in cellular differentiation,reproduction and apoptosis,as well as cellular adhesion and mobility,and genetic stability that is often lost in various human cancers.Recently,some studies have indicated that down-regulation of PTEN protein expression due to genetic or epigenetic changes,like mutation,loss of heterozygosity(LOH) and promoter ... |
| Keywords: | Phosphatase and tensin homolog deleted on chromosome ten Gastric cancer Carcinogenesis |
| 本文献已被 CNKI 等数据库收录！ | |