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| 蛋氨酸-胆碱缺乏饮食诱导的非酒精性脂肪性肝炎小鼠模型的建立及动态监测 | |
| 引用本文： | 苏冬梅,诸葛丽,李健,杨美娟,刘云霞,李军祥. 蛋氨酸-胆碱缺乏饮食诱导的非酒精性脂肪性肝炎小鼠模型的建立及动态监测[J]. 世界华人消化杂志, 2011, 0(11): 1122-1129 |
| 作者姓名： | 苏冬梅 诸葛丽 李健 杨美娟 刘云霞 李军祥 |
| 作者单位： | 北京中医药大学东方医院消化内科;北京中医药大学基础医学院人体形态学系; |
| 基金项目： | 2010年北京中医药大学自主选题基金资助项目,No.2009JYBZ2-XS070; 2010年北京市自然科学基金资助项目,No.7102094~~ |
| 摘 要： | 目的:研究蛋氨酸.胆碱缺乏(MCD)饮食诱导的非酒精性脂肪性肝炎(NASH)小鼠肝脏脂肪变性及炎症发生、发展的病理特点.方法:将40只C57/BL6小鼠随机分成2组,分别喂养MCD饮食(模型组)和对照蛋氨酸-胆碱充足(MCS)饮食(空白组),于造模的第1-5周动态连续取材,小鼠血清ALT、AST、TG及肝TG等生化指标... |
| 关 键 词： | 蛋氨酸胆碱缺乏饮食 非酒精性脂肪性肝炎 动态连续监测 小鼠 |
A mouse model of non-alcoholic steatohepatitis induced by feeding a methionine-choline-deficient diet:establishment and dynamic monitoring |
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| Dong-Mei Su,Li Zhuge,Yun-Xia Liu,Jun-Xiang Li. A mouse model of non-alcoholic steatohepatitis induced by feeding a methionine-choline-deficient diet:establishment and dynamic monitoring[J]. World Chinese Journal of Digestology, 2011, 0(11): 1122-1129 | |
| Authors: | Dong-Mei Su Li Zhuge Yun-Xia Liu Jun-Xiang Li |
| Affiliation: | Dong-Mei Su,Li Zhuge,Yun-Xia Liu,Jun-Xiang Li,Department of Gastroenterology,Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China Jian Li,Mei-Juan Yang,Human Morphology,Department of Basic Medical Sciences,Beijing 100029,China |
| Abstract: | AIM:To establish a mouse model of non-alcoholic steatohepatitis(NASH)by feeding a methionine-choline-deficient(MCD)diet and to dynamically monitor the pathological features of hepatic steatosis and inflammation in these mice.METHODS:Forty mice were randomly divided into two groups and fed an MCD diet or a me-thionine-choline-sufficient(MCS)diet.At weeks 1 to 5,these mice were sacrificed to take serum samples for biochemical measurements and liver samples for HE staining and oil red O staining to grade the d... |
| Keywords: | Methionine-choline-deficient diet Nonalcoholic steatohepatitis Dynamic monitoring Mice |
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