| 药敏试验方法的局限性及改进的建议 |
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| 引用本文： | 刘玉庆,张怀强,胡明,赵越,白华,金建玲,高培基.药敏试验方法的局限性及改进的建议[J].山东大学学报(医学版),2011,49(3):124-132. |
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| 作者姓名： | 刘玉庆 张怀强 胡明 赵越 白华 金建玲 高培基 |
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| 作者单位： | 1. 山东省畜禽疫病防治与繁育重点实验室,山东省农业科学院畜牧兽医研究所,济南,250100
2. 山东大学微生物技术国家重点实验室,济南,250100 |
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| 基金项目： | 国家自然科学基金资助课题(30770044); 山东省中青年科学家科研奖励基金资助课题(2006BS02008); 山东省自然科学基金资助课题(ZR2010HQ047、Y2007D35) |
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| 摘 要： | 以CLSI提出的两种细菌药敏试验方法(纸片扩散法和肉汤稀释法)和对"breakpoint"标准的拟定为例,基于菌群生长动力学和临床对抗菌药物选择的需要,分析现行药敏试验存在的问题,并就病原菌的生态学、breakpoint制定、药敏试验方法的规范和抗药性网络建设等方面提出建议。
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| 关 键 词： | 药敏试验 抗药性 耐药性 Breakpoint |
Methodological limitation of antimicrobial susceptibility tests and its improvement |
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| LIU Yu-qing,ZHANG Huai-qiang,HU Ming,ZHAO Yue,BAI Hua,JIN Jian-ling,GAO Pei-ji.Methodological limitation of antimicrobial susceptibility tests and its improvement[J].Journal of Shandong University:Health Sciences,2011,49(3):124-132. |
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| Authors: | LIU Yu-qing ZHANG Huai-qiang HU Ming ZHAO Yue BAI Hua JIN Jian-ling GAO Pei-ji |
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| Institution: | LIU Yu-qing1,ZHANG Huai-qiang2,HU Ming1,ZHAO Yue2,BAI Hua1,JIN Jian-ling2,GAO Pei-ji2 (1.Shandong Key Laboratory of Animal Disease Control and Breeding,Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Science,Jinan 250100,China,2.State Key Laboratory of Microbial Technology,Shandong University,China) |
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| Abstract: | Taking the disk diffusion method and broth dilution method and their breakpoint standard proposed by the Clinical and Laboratory Standards Institute(CLSI) as an example,problems of these classic antimicrobial susceptibility tests were analyzed based on bacterial growth kinetics and the clinical choice of antimicrobial drugs.Then recommendations were made in the ecology of pathogens,breakpoint division,methodological criteria for antimicrobial susceptibility tests,and the antimicrobial resistance monitoring ... |
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| Keywords: | Antimicrobial susceptibility testing Antimicrobial resistance Antimicrobial tolerance Breakpoint |
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