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| 电针对脊髓损伤后硫酸软骨素蛋白多糖表达的影响 | |
| 引用本文： | 赵伟. 电针对脊髓损伤后硫酸软骨素蛋白多糖表达的影响[J]. 山东大学学报(医学版), 2011, 49(3): 73-75,80 |
| 作者姓名： | 赵伟 |
| 作者单位： | 滨州医学院组织学与胚胎学教研室,山东,烟台,264003 |
| 基金项目： | 滨州医学院科技计划资助项目(BY2008KJ22) |
| 摘 要： | 目的观察电针对脊髓损伤后硫酸软骨素蛋白多糖(CSPGs)表达的影响,探讨电针对脊髓损伤修复的可能作用机制。方法将成年SD大鼠40只分为正常对照组、模型组和电针组。建立成年大鼠T9～T10段脊髓全横断损伤模型。除电针组于术后当天进行电针治疗外,3个组均分别于术后7、14、28 d取材,用免疫组织化学ABC法和图像分析技术检测脊髓内CSPGs的表达。结果术后7～28 d,与正常对照组相比模型组脊髓损伤邻近组织内CSPGs表达明显增强(P<0.05);与模型组相比,电针组脊髓损伤邻近组织内CSPGs表达明显受到抑制,差异显著(P<0.05)。结论电针能显著降低脊髓损伤后CSPGs的表达,从而减弱CSPGs对轴突再生的抑制作用,这可能是其促进脊髓损伤修复的可能机制之一。 |
| 关 键 词： | 电针 脊髓损伤 硫酸软骨素蛋白多糖 大鼠 |
Effects of electro-acupuncture on expression of CSPGs after spinal cord injury |
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| ZHAO Wei. Effects of electro-acupuncture on expression of CSPGs after spinal cord injury[J]. Journal of Shandong University:Health Sciences, 2011, 49(3): 73-75,80 | |
| Authors: | ZHAO Wei |
| Affiliation: | ZHAO Wei (Department of Histology and Embryology,Binzhou Medical University,Yantai 264003,Shandong,China) |
| Abstract: | Objective To explore the effect of electro-acupuncture on expression of chondroitin sulfate proteoglycans(CSPGs) in the injured tissue of the transected completely spinal cord,and its mechanism in the repair of spinal cord injury(SCI).Methods Forty adult rats were divided into the normal control group,the model group and the electroacupuncture group(EC group).All rats underwent completely transection between segments T9 and T10 of the spinal cord.Electro-acupuncture treatment started on the same day after o... |
| Keywords: | Electroacupuncture Spinal cord injuries Chondroitin sulfate proteoglycan Rats |
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