| 不同染毒次数和采样时间溴酸钾对小鼠骨髓细胞微核率的影响 |
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| 引用本文： | 李书香 张锦身. 不同染毒次数和采样时间溴酸钾对小鼠骨髓细胞微核率的影响[J]. 中国国境卫生检疫杂志, 1996, 19(5): 282-283 |
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| 作者姓名： | 李书香 张锦身 |
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| 作者单位： | 珠海卫生检疫局(李书香)，珠海卫生检疫局(张锦身) |
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| 摘 要： | 本实验以剂量为0．79g／kg(相当于1／2LD50)的溴酸钾乳化液对昆明种小鼠灌胃，以观察在不同条件下，受试物对小鼠骨髓细胞微核率的影响。实验结果显示，受试物诱发骨髓微核的最佳染毒次数为四次染毒，末次染毒后24小时是微核出现的高峰时间。本结果为致突变试验选择染毒次数和采样时间提供了依据。作者建议经国标法骨髓微核试验，结果是阴性的化合物。应采用多次染毒法重做试验。
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| 关 键 词： | 染毒次数 采样时间 溴酸钾 小鼠 骨髓细胞 微核率 影响 食品添加剂 致突变作用 |
The Effect of Potassium Bromate in different Contaminative Frequency and Sampling Time on the Micronuclear Rateof Marrow Cell in Mice |
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| Li Shuxiang Zhang Jinshen Zhuhai Health and Quarantine Bureau. The Effect of Potassium Bromate in different Contaminative Frequency and Sampling Time on the Micronuclear Rateof Marrow Cell in Mice[J]. Chinese Journal of Frontier Health and Quarantine, 1996, 19(5): 282-283 |
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| Authors: | Li Shuxiang Zhang Jinshen Zhuhai Health and Quarantine Bureau |
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| Affiliation: | Li Shuxiang Zhang Jinshen Zhuhai Health and Quarantine Bureau |
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| Abstract: | The mice of Kun-ming species were fed in Potassium Bromate at the dose of 0. 79g/kg, and the effect of Potassium Bromate on the micronuclear rate of marrow cell. The experiment showed that the best contaminative frequency that raised the micronucleus of marrow cell was four times. The highe peak time of arising micronucleus was by the end of 24h after the last contamination. the contaminative method and the sampling time of mutagenesis test were based on this result. The auther supposed that the multi-contamination should be used if the result was negitive by the micronuclus test according to the standard method. |
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| Keywords: | Potassium Bromate Contaminative frequency Sampling time Marrow cell Micronuelear rate |
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