香丹注射液心包灌洗预防心脏术后心包粘连的研究

目的 探讨香丹注射液通过心包引流管灌洗预防心包粘连形成的作用及作用机制.方法 20只大耳白兔随机分为对照组及实验组(每组10只),按作者自行改良的左侧开胸手术法建立心包粘连动物模型.对照组灌洗用药为生理盐水；实验组灌洗用药为香丹注射液(4％浓度),干预药物均通过心包引流管注入心包腔灌洗治疗.对纤维粘连蛋白指标检测并统计...

Preventive Effect of Xiangdan Injection on Pericardial Adhesions after Heart Surgery

Objective To study the preventive effect and mechanism of Xiangdan injection on pericardial adhesions.Methods Twenty Japanese flap-eared white rabbits were randomly divided into control group and experiment group（n=10 each）.The rabbit models with pericardial adhesions were established by the improved left-sided surgical approach presented by the authors.Experiment group received Xiangdan injection of 4% concentration by pericardial cavity perfusion.Control group received normal saline injection.The levels of fibronectin（FN） in the pericardial cavity were measured and statistically analyzed.The pathological and morphological changes of the pericardium were observed.Results After three days of drug administration,the FN levels were significantly different between the two groups.The pathological and morphological observation indicated significant difference in the pericardial adhesion degrees,which was lighter in experiment group.Conclusion Xiangdan injection can decrease the FN concentration in the pericardial cavity.The traditional Chinese drug is important to prevent the pericardial adhesions after surgery.