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| 老年男性骨质疏松与M-纤维凝胶蛋白基因多态性的关系 | |
| 引用本文： | 梁继兴,陈刚,曾月桂,陈彦,侯建明,林丽香. 老年男性骨质疏松与M-纤维凝胶蛋白基因多态性的关系[J]. 中华骨质疏松和骨矿盐疾病杂志, 2011, 4(4): 237-240. DOI: 10.3969/j.issn.1674-2591.2011.04.004 |
| 作者姓名： | 梁继兴 陈刚 曾月桂 陈彦 侯建明 林丽香 |
| 作者单位： | 1. 福建医科大学省立临床学院,福州,350001 2. 福建中医药大学,福州,350001 |
| 摘 要： | 目的探讨M-纤维凝胶蛋白基因（M—ficolin）的FCN1基因启动子1981碱基G〉A突变rs2989727多态性与老年男性骨质疏松症的关系。方法选择老年男性骨质疏松症患者108例，老年男性非骨质疏松症者（对照组）90例，检测骨密度和钙、磷、碱性磷酸酶等指标与M—ficolin的FCN1基因启动子1981碱基G〉A突变rs2989727多态性。结果老年男性骨质疏松症组与对照组M—ficolin的FCN1基因启动子1981碱基G〉A突变rs2989727多态性等位基因分布频率无统计学意义。结论FCN1基因M-ficolin的FCN1基因启动子1981碱基G〉A突变rs2989727多态性与老年男性骨质疏松发病可能无关。 |
| 关 键 词： | 骨质疏松 男性 骨密度 M-纤维凝胶蛋白基因多态性 |
Relationship between the polymorphism of M-ficolin and primary osteoporosis in aged men |
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| Affiliation: | LIANG Ji-xing , CHEN Gang , ZENG Yue-gui, et al 1. Fujian Provincial Clinical College of Fujian Medical University, Fuzhou 350001 ; 2. Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China |
| Abstract: | Objective To investigate the relationship between the polymorphisms of rs2989727 of M-ficolin （ FCN-1 ） and primary osteoporosis in aged Chinese men in Fuzhou. Methods In 108 osteoporosis and 90 control （ no- osteoporosis） （n = 90） aged Chinese men in Fuzhou, the genotypes and alleles of rs2989727 in FCN-1 gene were detected and analyzed by the polymerase chain reaction and gene sequencing techniques. Bone mineral density （BMD） were measured by dual energy X-ray absorptionmetry （DEXA） in the proximal femur （femoral neck, trochanter） and lumbar spine L2-L4. Results There were no significant differences of the FCN-1 gene polymorphisms in osteoporotic and control group aged men （ P 〉 0. 05）. Conclusion There is no relationship between rs2989727 polymorphisms of FCN-1 gene and osteoporosis in Chinese aged males in Fuzhou. |
| Keywords: | osteoporosis male bone mineral density M-ficolin gene polymorphism |
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