超敏C反应蛋白浓度在颅脑感染诊断中的价值

目的探讨颅脑疾病患者超敏C反应蛋白(high sensitive C-reactive protein,hs-CRP)浓度与白细胞(WBC)计数的相关性。方法采集431名住院患者血样,作hs-CRP浓度、WBC计数及中性粒细胞NEU百分比分类检测,计算出各自均值、异常率,各项指标异常率的显著性差异及hs-CRP浓度、WBC计数、NEU百分比三者的相关性。结果WBC计数大于10×109/L时,患者hs-CRP的浓度为(36.3±40.2)mg/L,与WBC计数小于10×109/L的患者比较,具有显著性差异(p<0.01);431名患者hs-CRP浓度、WBC计数及NEU百分比分别为:(22.53±31.91)mg/L、(10.49±4.64)×109/L、(69.10±14.66)%。hs-CRP浓度与WBC计数及NEU百分比的异常率分别为:90.3%、43.6%、51.0%。hs-CRP浓度异常率较WBC计数及NEU百分比两者均高,具有统计学差异(p<0.01);hs-CRP浓度与WBC计数及NEU百分比呈显著正相关(p<0.01,r=0.346,r=0.401),相关关系不密切。WBC计数与NEU百分比呈显著正相关(p<0.01,r=0.577),相关关系密切。结论在脑颅疾病中,hs-CRP浓度与WBC计数及NEU百分比呈正相关,Hs-CRP浓度大于36.3mg/L并持续升高时,提示感染的可能。

THE MEANING OF ULTRASENSITIVE C-REACTION PROTEIN CONCENTRATION IN DIAGNOSIS OF CRANIOCEREBRAL INFECTION

Objective to learn the relevance of high sensitive C - reactive protein（hs - CRP） concentration and the count of WBC in patients of brain disease. Methods Collect 431 blood samples of patients for their hs - CRP eoncentration,WBC counts and neutrophil （NEU） percentage of Category detection, calculated their average, abnormal rate, the rate of abnormal indicators significant difference in the concentration and hs -CRP , WBC count, NEU percentage among the relevant. Results Hs - CRP the concentration is （ 36. 3± 40. 2） mg/L when WBC count is more than 10 ×10^9/L, which has a a significant difference （p 〈 0. 01 ） with that whose WBC count is less than 10 ×10^9/L; 431 patients＇ hs - CRP concentration, WBC count and NEU% are as follow： （22. 53 ± 31.91 ） mg/L, （ 10. 49 ± 4. 64） ×10^9/L, （69.10 ± 14. 66） %. hs - CRP eoneentration and the WBC count and the percentage of the NEU abnormal rates are as follow： 90. 3% , 43.6% , 51.0%. hs -CRP concentration of abnormal rate has a significant difference （p 〈 0. 01 ）with the WBC count and NEU% ; hs -CRP concentration is positively correlated to the WBC count and NEU% （p 〈 0.01, r = 0. 346, r = 0. 401 ）, but not closely related. WBC count and NEU% are significantly correlated （p 〈 0. 01, r = 0. 577）, associated closely related. Conclusion hs - CRP concentration is positively correlated to the WBC count and NEU% in brain disease, when Hs - CRP concentration is greater than 36.3 mg/L and continued to rise, it prompts the possibility of infection.