| p27~(kip1)在前列腺上皮内瘤细胞中的表达 |
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| 引用本文： | 叶定伟!200433上海,李慧!200433上海,Richard Land,钱松溪!200433上海,孙颖浩!200433上海,郑家富!200433上海,马永江!200433上海. p27~(kip1)在前列腺上皮内瘤细胞中的表达[J]. 中华泌尿外科杂志, 2001, 0(7) |
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| 作者姓名： | 叶定伟!200433上海 李慧!200433上海 Richard Land 钱松溪!200433上海 孙颖浩!200433上海 郑家富!200433上海 马永江!200433上海 |
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| 作者单位： | 第二军医大学长海医院泌尿外科(叶定伟!200433上海，钱松溪!200433上海，孙颖浩!200433上海，郑家富!200433上海，马永江!200433上海)，第二军医大学长海医院内分泌科(李慧!200433上海)，美国得州大学安德逊癌症中心(Richard Land) |
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| 摘 要： | 目的 研究前列腺上皮内瘤 (PIN)细胞中 p2 7kip1的表达。 方法 采用免疫组织化学分析法 ,检测 2 2例人前列腺标本中PIN细胞p2 7kip1蛋白的表达。 结果 在 2 2例人前列腺标本中 ,高分级PIN灶细胞中 p2 7kip1蛋白表达与周边前列腺上皮细胞比较均有降低。 结论 p2 7kip1蛋白表达降低可能和PIN的形成有关。
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| 关 键 词： | 前列腺肿瘤 细胞周期 |
Expression of p27~(kip1) in prostatic intraepithelial neoplasia cells |
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| YE Dingwei ,LI Hui,Richard Land,et al.. Expression of p27~(kip1) in prostatic intraepithelial neoplasia cells[J]. Chinese Journal of Urology, 2001, 0(7) |
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| Authors: | YE Dingwei LI Hui Richard Land et al. |
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| Affiliation: | YE Dingwei *,LI Hui,Richard Land,et al. *Department of Urology,Changhai Hospital,The Second Military Medical University,Shanghai 200433,China |
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| Abstract: | Objective To investigate the expression of p27 kip1 protein in prostatic intraepithelial neoplasia cells. Methods In 22 human prostatic samples, the expression of p27 kip1 protein in high grade prostatic intraepithelial neoplasia cells was evaluated by using immunohistochemical analysis. Results The expression of p27 kip1 in prostatic intraepithelial neoplasia cells was weaker than in adjacent prostatic epithelial cells in all the 22 prostate samples. Conclusions Decrease of the p27 kip1 expression may play a role in the development of PIN which may be an premalignant lesion. |
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| Keywords: | Prostatic neoplasms Cell cycle |
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