| 重组促胰岛素分泌素对2型糖尿病患者血浆FGF-21水平的影响 |
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| 引用本文： | 董靖,杨刚毅,李伶,刘东,方李钶,李生兵,陈文雯.重组促胰岛素分泌素对2型糖尿病患者血浆FGF-21水平的影响[J].中国老年学杂志,2011,31(9). |
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| 作者姓名： | 董靖 杨刚毅 李伶 刘东 方李钶 李生兵 陈文雯 |
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| 作者单位： | 1. 重庆医科大学附属第二医院内分泌科,重庆,400010
2. 重庆医科大学检验系临床生化教研室和教育部实验诊断重点实验室 |
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| 摘 要： | 目的 探讨注射用重组促胰岛素分泌素(recombinant exendin-4 for injection,E-4)治疗对2型糖尿病(T2DM)患者血浆成纤维细胞生长因子-21(FGF-21)水平的影响.方法 采用酶联免疫法测定40例健康对照和33例T2DM患者血浆FGF-21水平以及使用E-4治疗前后的变化,探讨血浆FGF-21水平与体重指数(BMI)、腰臀比(WHR)、血脂、血糖及胰岛素等的关系.结果 T2DM患者血浆FGF-21水平明显升高(2.16±0.20)vs(1.53±0.36)μg/L,P<0.05].多元逐步回归分析表明,HbAlc及TG是影响血浆FGF-21水平的独立危险因素(YFGF-21=1.370+0.069XHbAlc+0.056XTG).E-4治疗后T2DM患者血浆FGF-21水平明显低于用药前(2.15±0.21)vs(1.99±0.12)μg/L,P<0.05].结论 T2DM患者血浆FGF-21水平改变可能与其代谢紊乱和胰岛素抵抗有关,并可能是E-4作用的生物靶点之一.
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| 关 键 词： | 成纤维细胞生长因子-21 2型糖尿病 重组促胰岛素分泌素 |
Effects of administration with recombinant exendin-4 on fasting plasma FGF-21 levels in type 2 diabetes mellitus patients |
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| DONG Jing,YANG Gang-Yi,LI Ling,et al..Effects of administration with recombinant exendin-4 on fasting plasma FGF-21 levels in type 2 diabetes mellitus patients[J].Chinese Journal of Gerontology,2011,31(9). |
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| Authors: | DONG Jing YANG Gang-Yi LI Ling |
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| Institution: | DONG Jing,YANG Gang-Yi,LI Ling,et al.Department of Endocrinology,Second Affiliated Hospital,Chongqing University of Medical Science,Chongqing 400010,China |
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| Abstract: | Objective To investigate the effects of recombinant exendin-4(E-4) on plasma fibroblast growth factor-21(FGF-21) levels in patients with type 2 diabetes mellitus(T2DM).Methods 33 T2DM patients with plasma glucose poorly controlled undergone oral hypoglycemic agents(OHA) therapy were divided into control and test groups.14 patients of control group were administrated with original OHA therapy for 12 w,while 19 patients of test group were administrated with abdominal subcutaneous injection of E-4 together wit... |
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| Keywords: | Fibroblast growth factor-21 Type 2 diabetes mellitus Recombinant exendin-4 for injection |
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