KAI1及Caveolin-1在胃癌组织中的表达及其意义

目的探讨正常胃黏膜、不典型增生胃黏膜及胃癌组织中KAI1及Caveolin-1蛋白的表达。方法应用免疫组化SP法检测22例正常胃黏膜、65例不典型增生胃黏膜及74例胃癌组织中KAI1蛋白、Caveolin-1蛋白的表达状况。结果正常胃黏膜、不典型增生胃黏膜及胃癌组织中,KAI1和Caveolin-1阳性率呈递减趋势,且组间差异有显著性（χ2=24.022,P〈0.05;χ2=44.315,P〈0.05）。经χ2和Fisher精确概率法检验,KAI1蛋白的表达在不同浸润深度、有无淋巴结转移组、有无脉管侵犯组内表达率的差异有显著性（P〈0.05）,在年龄及性别组内表达率的差异性无显著性（P〉0.05）。Caveolin-1蛋白阳性表达率与有无淋巴结转移、浸润深度有关（P〈0.05）,而与有无脉管转移、年龄及性别（P〉0.05）无关。Spearman等级相关分析显示,KAI1蛋白与Caveolin-1蛋白表达呈正相关（rs=0.827,P〈0.05）。结论 KAI1、Caveolin-1在胃癌组织中表达的下调甚至缺失可能是胃癌发生、发展以及浸润转移的重要原因之一。

Expressions and significances of KAI1 and Caveolin-1 in gastric carcinomas

Objective To investigate the expressions of KAI1 and Caveolin-1 proteins in normal gastric mucosa,gastric atypical hyperplasia and gastric carcinomas tissues.Methond The expression of KAI1 and Caveolin-1 proteins in 22 cases of normal gastric mucosa,65 cases of gastric atypical hyperplasia,74 cases of gastric carcinoma were detected by SP immunohistochemistry method.Results There were decreasing tendency of the positive expression rates of KAI1 and Caveolin-1 in normal gastric mucosa and gastric atypical hyperplasia tissues,which had statistical significance during groups（P0.05）.Fisher′s exact ratio test showed that the expression of KAI1 protein in gastric carcinoma was correlated to the depth of infiltration of carcinoma,vessel invasion and lymph node metastasis（P0.05）,but not to with patients′ age and gender（P 0.05）.Expression of Caveolin-1 protein was related to invasion depth or lymph node metastases（P0.05）,but not to vessel invasion,patients′ age and gender（P 0.05）.Spearman rank correlation analysis indicated that the expression of KAI1 was positive relevant to the expression of Caveolin-1（rs=0.827,P0.05）.Conclusion The down-regulation and absence of KAI1 and Caveolin-1 proteins may be one of the important causes for the onset,development and progression of gastric carcinomas.