131I治疗前抗甲状腺药物对Graves甲状腺功能亢进的影响

目的：探讨运用131 I治疗Graves甲状腺功能亢进（甲亢）前先较长时间服用抗甲状腺的药物对Graves甲亢治愈率的影响。方法将临床明确诊断为Graves甲亢的100例患者按是否经过抗甲状腺药物（ATD）治疗，分为对照组和治疗组，对照组为用ATD治疗最少半年而未愈的患者，治疗组为未经ATD治疗的患者，两组患者同时采用131 I治疗。结果对照组的治愈率为72％，治疗组的治愈率为98％，治疗组明显高于对照组；两组治疗后的甲状腺功能比较，治疗组的治疗结果也显著优于对照组，差异有统计学意义（P＜0．05）。结论131 I治疗Graves甲亢前较长时间的应用ATD能够降低131 I对Graves甲亢的治愈率，从而影响其疗效。

Effects of treatment of anti-thyroid drugs before 131 I therapy on Graves'hyperthyroidism

Objective To investigate the effects of long‐term application of anti‐thyroid drugs （ATD） before 131 I treatment on Graves′hyperthyroidism .Methods A total of 100 patients with Graves′hyperthyroidism were divid‐ed into two groups ,including control group ,patients in which were treated with ATD for at last six months but not healed ,and treatment group ,patients in which were not treated with ATD .Patients in both groups were then treated with 131 I .Results Cure rates of treatment group was 98% ,higher than the 72% of control group ,and thyroid func‐tion of patients in treatment group were also better than control group （P〈 0 .05） .Conclusion Long‐term ATD treatment might affect curative effect of 131 I therapy for the treatment of Graces′hyperthyroidism ,and decrease the cure rate .