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Evaluation by computerized axial tomography of eclamptic women with seizures refractory to magnesium sulfate therapy
Authors:R Dunn  W Lee  D B Cotton
Affiliation:1. Temple University Hospital, Philadelphia, Pennsylvania;2. Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania;1. Department of Nursing, Hospital of the University of Pennsylvania, 3400 Spruce Street, 2nd Floor Rhoads Building, Philadelphia, PA 19104, USA;2. Department of Neurology, University of Pennsylvania, 3400 Spruce Street, 3 West Gates Building, Philadelphia, PA 19104, USA;3. Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, 3 West Gates Building, Philadelphia, PA 19104, USA;4. Penn Presbyterian Medical Center, Philadelphia, PA 19104, USA;5. Department of Neurosurgery, University of Pennsylvania, 3400 Spruce Street, 3 West Gates Building, Philadelphia, PA 19104, USA;1. Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt;2. Endemic Medicine and Hepatology Department, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt;3. Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt
Abstract:
Over a 1-year period, seven eclamptic patients with repetitive seizures while receiving therapeutic levels of intravenous magnesium sulfate were evaluated by computerized axial tomography. In five patients brain abnormalities were identified, which included diffuse cerebral edema (one), cerebral venous thrombosis (two), and low density white matter (two). Clinical management of eclamptic women on the basis of structural central nervous system abnormalities documented by computerized tomography appears to warrant further investigation.
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