| 拉呋替丁鼠伤寒沙门氏菌基因回复突变试验 |
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| 引用本文： | 朱燕,张强,周玲,胡志力.拉呋替丁鼠伤寒沙门氏菌基因回复突变试验[J].齐鲁药事,2005,24(1):48-49. |
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| 作者姓名： | 朱燕 张强 周玲 胡志力 |
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| 作者单位： | 山东省医学科学院药物研究所,济南,250062 |
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| 摘 要： | 目的 体外观察拉呋替丁能否诱发鼠伤寒沙门氏菌组氨酸营养缺陷型突变株的回复突变。方法 Ames试验用TA97、TA98、TA10 0、TA10 2菌株并分加与不加肝微粒体酶活化系统( +/ -S9)试验。结果 拉呋替丁对四个菌株各剂量组的回复菌落数都未超过自然回复菌落数,Ames试验结果为阴性。结论 未见拉呋替丁致突变性。
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| 关 键 词： | 拉呋替丁 Ames试验 致突变性 |
| 文章编号： | 1672-7738(2005)01-0048-02 |
Effect of Rafutidine on Salmonella typhimurium gene reverse mutation |
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| Zhu Yan,Zhang Qiang,Zhou Ling,Hu Zhi-li.Effect of Rafutidine on Salmonella typhimurium gene reverse mutation[J].qilu pharmaceutical affairs,2005,24(1):48-49. |
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| Authors: | Zhu Yan Zhang Qiang Zhou Ling Hu Zhi-li |
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| Abstract: | Objective To test whether Rafutidine can induce in vitro reverse mutation of Salmonella typhimurium histamine-auxotroph mutant.Methods Ames test,used TA97,TA98,TA100 and TA102 tester strains of Salmonella typhimurium with or without the addition of liver microsomal enzyme activation system(+/-S 9) was carried out.Results The number of Rafutidine induced revertant colonies had no markedly difference with that of spontaneously revertant colonies with the 4 tester strains at a series of Rafutidine doses.Therefore,the Ames test gave negative result for Rafutidine.Conlusion Rafutidine does not express mutagenesis. |
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| Keywords: | Rafutidine Ames test mutagenesis |
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