105株志贺菌流行菌株的血清分型及耐药性分析

目的　调查志贺菌在上海地区流行的主要血清型和耐药性。方法　收集临床分离的志贺菌 1 0 5株进行生化鉴定、血清学分型和抗生素敏感性试验。结果　 1 0 5株志贺菌中 5 1株为宋氏志贺菌 ,占 4 8.6 % ;5 4株为福氏志贺菌 ,占 5 1 .4 % (包括 5株福氏变异株 ,占总数的 4 .7% )。宋氏志贺菌对抗菌药物的敏感率依次为氟喹诺酮类 1 0 0 %、头孢噻肟 94 .1 %。而福氏志贺菌对抗菌药物的敏感率依次为头孢噻肟 98.1 %、氟喹诺酮类70 %。结论　上海地区志贺菌感染以福氏志贺菌和宋氏志贺菌为主 ,福氏志贺菌中以福氏 2型为主 ,占 6 6 .7% ,其次为福氏 1型 ,占 2 0 .4 %。福氏志贺菌对各种抗生素耐药性有增高趋势 ,必须引起临床重视

Serotyping and susceptibility test of 105 Shigella spp strains

Objective To investigate serotype and antibiotics resistance of Shigella in Shanghai. Methods 105 clinical isolated Shigella spp strains were collected and identified. The serotyping and the susceptibity testing were performed. Results Of 105 strains, 51 strains (48.6%) were S sonnei and 54 strains (51.4%) were S flexneri . Of S flexneri , 66.7% were serotype 2 and 20.4% were serotype 1. The susceptibility rates of S sonnei to fluoroquinolones and cefotaxime were 100% and 94.1% respectively. The susceptibility rate of S flexneri to cefotaxime was 98.1% while the rate to fluoroquinolones was about 70%. Conclusions In Shanghai the main serotype of Shigella spp are S sonnei and S flexneri. Most of Shigella spp (especialy S flexneri ) are multidrug resistant. Susceptibility testing should be performed to guide the reasonable application of antibiotics.