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Identification of the central vestibular projections in man: a positron emission tomography activation study |
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| Authors: | Gabriella Bottini Roberto Sterzi Eraldo Paulesu Giuseppe Vallar Stefano F. Cappa Francesco Erminio Richard E. Passingham Chris D. Frith Richard S. J. Frackowiak |
| Affiliation: | (1) MRC Cyclotron Unit, Hammersmith Hospital, Du Cane Road, W12 OHS London, UK;(2) Divisione Neurologia, Ospedale Niguarda, Piazza Ospedale 5, I-20139 Milan, Italy;(3) Dipartimento di Psicologia, Universita' !["ldquo"]("/content/v337362gv16659v1/xlarge8220.gif") La Sapienza!["rdquo"]("/content/v337362gv16659v1/xlarge8221.gif") , Via dei Marsi 78, I-00185 Rome, Italy;(4) Divisione Neurologia II, Ospedale Civile, Universita' di Brescia, P.le Ospedale 1, I-25125 Brescia, Italy;(5) Department of Experimental Psychology, University of Oxford, South Park Road, OX1 3UD Oxford, UK;(6) Psychology Department, University College of London, Gower Street, WC1 E6TB London, UK |
| Abstract: | The cerebral representation of space depends on the integration of many different sensory inputs. The vestibular system provides one such input and its dysfunction can cause profound spatial disorientation. Using positron emission tomography (PET), we measured regional cerebral perfusion with various vestibular stimulations to map central vestibular projections and to investigate the cerebral basis of spatial disorientation. We showed that the temporoparietal cortex, the insula, the putamen, and the anterior cingulate cortex are the cerebral projections of the vestibular system in man and that the spatial disorientation caused by unilateral vestibular stimulation is associated with their asymmetric activation. |
| Keywords: | Vestibular system Representation of space Positron emission tomography Unilateral neglect Human |
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