| Maspin在65例乳腺癌中的表达及其临床意义 |
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| 引用本文： | 杨伟萍,韦长元,周建华,丁战铃,李航.Maspin在65例乳腺癌中的表达及其临床意义[J].肿瘤学杂志,2010,16(3):163-167. |
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| 作者姓名： | 杨伟萍 韦长元 周建华 丁战铃 李航 |
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| 作者单位： | 广西医科大学附属肿瘤医院,广西南宁,530021 |
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| 基金项目： | 广西科技厅科学基金项目(桂科青0339032) |
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| 摘 要： | 目的]研究乳腺癌中Maspin基因的表达情况及临床意义。方法]应用免疫组化S-P法检测77例乳腺病变组织（12例良性病变,65例乳腺癌）Maspin表达情况,结合临床、病理形态学资料分析其临床意义。结果]12例良性乳腺病变组织中Maspin蛋白阳性率100%,65例乳癌组织中Maspin蛋白阳性率30.8%（20/65）,差异有显著性（P〈0.01）。乳腺癌中Maspin的表达与ER、淋巴结转移、组织学类型和组织学分级有关（P〈0.05）。Spearman等级相关分析显示Maspin表达与腋淋巴结转移、临床分期、组织学分级呈负相关,Logistic多因素回归分析显示腋淋巴结转移、ER和组织学分级是Maspin蛋白阳性表达的影响因素（P〈0.05）。结论]Maspin蛋白可作为乳腺癌内分泌治疗肿瘤恶性转化、转移和预后评估的一个重要指标。
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| 关 键 词： | 乳腺肿瘤 Maspin 免疫组织化学 预后 |
Expression of Maspin in 65 Cases with Breast Cancer and its Significance |
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| YANG Wei-ping,WEI Chang-yuan,ZHOU Jian-hu,et al..Expression of Maspin in 65 Cases with Breast Cancer and its Significance[J].Journal of Oncology,2010,16(3):163-167. |
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| Authors: | YANG Wei-ping WEI Chang-yuan ZHOU Jian-hu |
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| Institution: | YANG Wei-ping,WEI Chang-yuan,ZHOU Jian-hua,et al.(Affiliated Tumor Hospital,Guangxi Medical University,Nanning 530021,China) |
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| Abstract: | Purpose] To investigate the expression of Maspin in breast cancer and its clinical significance.Method] The expression of Maspin in 77 cases(12 cases with benign breast lesion and 65 cases with breast cancer) with mastopathy tissue was detected by SP immunohistochemical method,and its clinical significance were analyzed.Results] Positive expression rate of Maspin was 100% in 12 benign breast lesions and 30.8% in 65 cases with breast cancer,with significant difference(P<0.01).The expression of Maspin in b... |
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| Keywords: | breast neoplasms Maspin immunohistochemical prognosis |
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