经鼻持续气道正压通气治疗睡眠呼吸暂停低通气综合征合并冠心病临床研究

目的 探讨经鼻持续气道正压通气(nCPAP)治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并冠心病的疗效和机制.方法 选择OSAHS合并冠心病患者126例,随机分为2组,观察组在原药物治疗基础上加用nCPAP治疗,对照组继续原药物治疗3个月,观察动态心电图变化,单纯药物及药物联合nCPAP治疗效果.结果 2组比较,夜间心肌缺血发生率明显下降(55.6%和6.35%,P＜0.05).结论 nCPAP治疗可以消除呼吸暂停,纠正低氧血症,降低夜间平均心率和平均收缩压,降低心肌缺血发生率,从而降低心血管终点事件发生率.

Nasal continuous positive airway pressure in the treatment of obstructive sleep apnea/hypopnea syndrome with coronary heart disease

Objective To observe the effect and mechanism of nasal continuous positive airway pressure(nCPAP)in the treatment of obstructive sleep apnea/hypopnea syndrome(OSAHS)with coronary heart disease.Methods 126 OSAHS patients with coronary heart disease were randomly divided into two groups.The treatment group was treated by nCPAP on the basis of former medicine but the control group was treated by former methods.Three months later,polysomnography(PSG)and the holter ECG examination were conducted.Results After three months,the nocturnal myocardial ischemia episodes decreased significantly in both groups(55.6%and 6.35%,P＜0.01).Conclusion nCPAP may abolish sleep apnea and hypopnea,correct hypoxemia,reduce the nocturnal mean heart rate and systolic blood pressure,and improve myocardial ischemia episodes,so to reduce the incidence of cardiac end-point events.