| GDF-15和NT-proBNP与肥厚型梗阻性心肌病心功能及心脏磁共振指标的相关性分析 |
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| 引用本文： | 吴超,赵雪燕,袁晋青,李建军,乔树宾,杨跃进.GDF-15和NT-proBNP与肥厚型梗阻性心肌病心功能及心脏磁共振指标的相关性分析[J].中国分子心脏病学杂志,2019(3):2914-2917. |
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| 作者姓名： | 吴超 赵雪燕 袁晋青 李建军 乔树宾 杨跃进 |
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| 作者单位： | 中国医学科学院北京协和医学院国家心血管病中心阜外医院心血管病国家实验室 |
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| 摘 要： | 目的评价生长分化因子-15(GDF-15)和N末端P型利钠肽原(NT-proBNP)与肥厚型梗阻性心肌病(HOCM)纽约心脏病协会(NYHA)心功能分级及心脏磁共振(MRI)指标的相关性。方法连续入选在阜外医院住院的HOCM患者29例,测定所有患者的GDF-15和NT-proBNP的血浆浓度;同时进行MRI检查。结果在HOCM中,发现Log(GDF-15)与NYHA心功能分级呈显著正相关(r=0.578,P<0.001),而NT-proBNP与纽约心脏病协会NYHA心功能分级未见相关性(r=0.126,P=0.514)。单变量分析和多元逐步回归分析,Log(GDF-15)与NT-proBNP与MRI所测得的左房内径,左室舒张末期内径,室间隔厚度,左室后壁厚度及左室流出道压差均未见显著相关性(P均>0.05)。Log(GDF-15)与Log(NT-proBNP)亦不具有相关性(r=-0.082,P=0.671)。结论 GDF-15可反映HOCM患者心功能的严重程度,但NT-proBNP并不能监测HOCM心功能的进展程度。两者对于HOCM者MRI指标的相关性价值有限。
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| 关 键 词： | 生长分化因子-15 N末端B型利钠肽原 肥厚型梗阻性心肌病 磁共振 |
Association of growth differentiation factor 15 and N-terminal pro-B type natriuretic peptide with NYHA grade and magnetic resonance imaging parameters in hypertrophic obstructive cardiomyopathy |
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| WU Chao,ZHAO Xue-yan,YUAN Jin-qing,LI Jian-jun,QIAO Shu-bin,YANG Yue-jin.Association of growth differentiation factor 15 and N-terminal pro-B type natriuretic peptide with NYHA grade and magnetic resonance imaging parameters in hypertrophic obstructive cardiomyopathy[J].Molecular Cardiology of China,2019(3):2914-2917. |
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| Authors: | WU Chao ZHAO Xue-yan YUAN Jin-qing LI Jian-jun QIAO Shu-bin YANG Yue-jin |
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| Institution: | (Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 100037, Beijing, China) |
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| Abstract: | WU Chao;ZHAO Xue-yan;YUAN Jin-qing;LI Jian-jun;QIAO Shu-bin;YANG Yue-jin(Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 100037, Beijing, China) |
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| Keywords: | Growth differentiation factor 15 N-terminal pro-B type natriuretic peptide Hypertrophic obstructive cardiomyopathy Magnetic resonance imaging |
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