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NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly
Institution:1. Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA;2. Department of Pathology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA;3. Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, China;4. Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA;5. Cancer Metabolism and Signaling Networks Program, Sanford-Burnham-Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA;1. Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan;2. Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan;1. Department of Medicine, University of California San Diego, La Jolla, CA, USA;2. Department of Surgery, University of California San Diego, La Jolla, CA, USA;3. Department of Pharmacology, University of California San Diego, La Jolla, CA, USA;4. Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA;5. Department of Medicine, McGill University and the McGill University Health Center, Montreal, QC, Canada;6. Department of Biology, University of North Carolina at Charlotte, Charlotte, NC, USA;7. Southern California Research Center for ALPD and Cirrhosis, Department of Pathology, Keck School of Medicine of USC, Los Angeles, CA, USA;8. Department of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA;9. Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA;1. Internal medicine department, Military Hospital, Mexico;2. Laboratory of Conservation Medicine, Higher School of Medicine, Instituto Politécnico Nacional, Mexico;3. Instituto Nacional de Ciencias Medicas y Nutrición“Salvador Zubiran”, Mexico City, Mexico;4. Gastroenterology Section of the Central Military Hospital, Mexico City, Mexico;5. Internal medicine department of Central Military Hospital, Mexico City, Mexico;1. Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA;2. College of Medical Laboratory Science and Technology, Harbin Medical University (Daqing), Daqing, Heilongjiang, PR. China;3. Center for Translational Biomedical Research and Department of Nutrition, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC, USA;4. Department of Gastroenterology, Tongji Medical College and The Central Hospital of Wuhan, Huazhong University of Science and Technology, Wuhan, Hubei, PR. China;5. Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA;1. Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ 85721, USA;2. Department of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, AZ 85721, USA;3. Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA;1. Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China;2. Department of Hepatic Surgery, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510006, China;3. Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Abstract:
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  • Keywords:p62/SQSTM1  Autophagy  NRF2  HSOS  Hepatomegaly  AKT  PDGFR  EGFR
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