Correlation between serum levels of endothelin-1 and disease severity in patients with neuromyelitis optica spectrum disorders |
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| Affiliation: | 1. Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark;2. Aarhus University, Aarhus, Denmark;3. Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark;4. Department of Medical Endocrinology, Rigshospitalet, Copenhagen, Denmark;5. Department of Biomedicine, Aarhus University, Aarhus, Denmark;6. Steno Diabetes Center Copenhagen, Gentofte, Denmark;7. Steno Diabetes Center, Sjaelland, Denmark;8. University of Copenhagen, Copenhagen, Denmark;1. Área Inmunología, DEPBIO/IQB - Facultad de Química/Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay;2. Integrative Parasitology, Center for Infectious Diseases, Heidelberg University, Heidelberg, Germany;1. Department of Medical Cell Biology, Institute for Anatomy and Cell Biology, Medical Faculty, Philipps-University of Marburg, Robert-Koch-Str. 8, 35037, Marburg, Germany;2. Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health Intramural Research Program, Bethesda, 20814, Maryland, USA;1. Federal State Budgetary Scientific Institution, Research Institute of Obstetrics, Gynecology, and Reproductology Named after D.O. Ott, Russia;2. Federal State Budgetary Scientific Institution, Research Institute of Experimental Medicine, Russia;3. Saint Petersburg State Budgetary Healthcare Institution, City Hospital No. 26, Russia;1. Institute of Food Sciences, National Research Council, Avellino, Italy;2. Department of Biomolecular Innovation, Institute for Biomedical Sciences, Shinshu University, 8304 Minamiminowa, Kamiina, Nagano 399-4598, Japan;3. Hiroshima University, Graduate School of Biosphere Science, Hiroshima, Japan;1. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran;2. Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;3. Department of Cell and Molecular Biology, Islamic Azad University, Science and Research Branch. Tehran, Iran;4. Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran;5. School of Medicine, Bandar Abbas University of Medical Science, Bandar Abbas, Iran;6. Department of Medical Genetics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran |
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| Abstract: | AimsNeuromyelitis optica spectrum disorders (NMOSD) are aquaporin-4 antibody-mediated diseases of the central nervous system. Endothelin-1 (ET-1) is an inflammatory cytokine released by vascular endothelial cells and activated astrocytes. Previous studies have reported the aberrant expressions of cytokines/chemokines in patients diagnosed with NMOSD. However, the serum levels of ET-1 in NMOSD patients remain unknown. The purpose of this study was to measure the serum levels of ET-1 and other immune-related cytokines/chemokines in patients with NMOSD, and to investigate the correlation between serum ET-1 levels and clinical characteristics of NMOSD.MethodsThirty-eight patients with NMOSD and twenty-eight healthy controls (HCs) were recruited in this study. The serum concentrations of ET-1 and other cytokines/chemokines were measured, and their correlations to the clinical features of patients with NMOSD were analyzed.ResultsThe serum levels of ET-1 in patients with NMOSD were significantly higher than those in HCs (P = 0.0001). The serum concentrations of ET-1 were positively correlated with the Expanded Disability Status Scale score (r = 0.428, P = 0.0183). High-dose intravenous methylprednisolone treatment significantly reduced the levels of ET-1 and interleukin (IL)-6 in blood, but significantly increased the serum concentrations of IL-10 in NMOSD patients. No correlations were found between serum ET-1 levels and the concentrations of other cytokines/chemokines in these patients.ConclusionET-1 and IL-6 might exert pro-inflammatory effects in the pathogenesis of NMOSD, whereas IL-10 played an anti-inflammatory role in this process. ET-1 might be a potential biomarker for predicting the severity of NMOSD. However, the serum levels of ET-1 were not correlated with the changes of other cytokines/chemokines in patients with NMOSD. The involvement of ET-1 in the development of NMOSD needs to be further studied. |
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| Keywords: | Endothelin-1 Inflammatory cytokines Neuromyelitis optica spectrum disorders Aquaporin-4 antibody |
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