| E-test检测念珠菌对5种抗真菌药物敏感性试验 |
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| 引用本文： | 陈桂山,梁锦胜,卢兰芬,吴秀娟,冯雪琴,吴剑杨. E-test检测念珠菌对5种抗真菌药物敏感性试验[J]. 岭南皮肤性病科杂志, 2003, 10(3): 148-150 |
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| 作者姓名： | 陈桂山 梁锦胜 卢兰芬 吴秀娟 冯雪琴 吴剑杨 |
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| 作者单位： | 广东省中山市人民医院,528400 |
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| 摘 要： | 目的：评价E-test检测念珠菌和酵母菌对5种抗真菌药物敏感性的临床应用价值。方法：以白念珠菌ATCC90028为标准质控菌株，用E-test方法与NCCLS M27-A方法同时检测137株临床分离酵母菌对5-氟胞嘧啶、氟康唑、两性霉素B、伊曲康唑、酮康唑5种药物敏感性，观察两所测得结果符合率。结果：5-氟胞嘧啶和两性霉素B敏感性较高，MIC和MIC50值小，与M27-A方法测得结果的总符合率均为94．2％；氟康唑、伊曲康唑和酮康唑的MIC和MIC50值最大，出现一定耐药性，总符合率分别为83．0％、74．5％和79．6％。结论：E-test法检测念珠菌对5种抗真菌药物敏感性与NCCLSM27-A参考方法符合率较高，操作简单，结果可靠。
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| 关 键 词： | E-test 检测 念珠菌 抗真菌药物 敏感性试验 |
| 修稿时间： | 2003-01-20 |
Susceptibility of Isolates of Candida to Five Antifungal Agents by E- test |
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| Chen Guishan,Liang Jinsheng,Lu Lanfen,et al.. Susceptibility of Isolates of Candida to Five Antifungal Agents by E- test[J]. Southern China Journal of Dermato-Venereology, 2003, 10(3): 148-150 |
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| Authors: | Chen Guishan Liang Jinsheng Lu Lanfen et al. |
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| Affiliation: | Chen Guishan,Liang Jinsheng,Lu Lanfen,et al. Department of Laboratory Medicine,Zhongshan People's Hospital,Guangdong 528400,China. |
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| Abstract: | Objective:To evaluate antifungal susceptibility by E-test in Candida Spp. Methods:The QC isolate of Candida Albicans (ATCC90028) was tested as control. Susceptibilities to 5-Fluorocytosine Amphotericin B Fluconazole Ketoconazole Itraconazole of 137 isolates was assessed by E-test and the NCCLS standard method (M-27A), respectively. Results:The MICs and MIC 50 of 5-Fluorocytosine Amphotericin B were less than azoles drugs, and the reproducibility of E-test was good. Conclusion:This study indicated that the antifungal susceptibility by E-test can be conveniently performed in clinical laboratory. |
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| Keywords: | Candida E-test Susceptibility |
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