| 人参二醇组皂甙对内毒素休克鼠5-羟色胺含量的影响 |
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| 引用本文： | 刘媛媛,吕美德,赵雪俭,王忠山,赵丹. 人参二醇组皂甙对内毒素休克鼠5-羟色胺含量的影响[J]. 吉林大学学报(医学版), 1991, 0(4) |
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| 作者姓名： | 刘媛媛 吕美德 赵雪俭 王忠山 赵丹 |
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| 作者单位： | 白求恩医科大学第一临床医学院传染科(刘媛媛，吕美德)，白求恩医科大学基础医学部病生教研室(赵雪俭，王忠山)，白求恩医科大学基础医学部病生教研室(赵丹) |
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| 摘 要： | 将128只Wistar大鼠随机分成内毒素休克组(ESG),内毒素休克·人参二醇组皂甙预治疗组(ESPG),对照组(CG)。分别观察注药后3h、8h、16h血清和组织5-羟色胺(5-HT)含量的变化,结果发现ESPG组血清和组织5-HT含量低于ESG组(P<0.05)说明人参二醇组皂甙可以抑制5-HT的释放或加速其分解,从而减轻肺动脉高压,改善微循环。
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| 关 键 词： | 内毒素休克 人参二醇组皂甙 5-羟色胺 |
EFFECT OF PANAXADIOL SAPONIN ON 5-HT IN RATS WITH ENDOTOXIC SHOCK |
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| Liu Yuanyuan,Lu Meide,Zhao Xuejian Wang Zhongshan,Zhao Dan. EFFECT OF PANAXADIOL SAPONIN ON 5-HT IN RATS WITH ENDOTOXIC SHOCK[J]. Journal of Jilin University: Med Ed, 1991, 0(4) |
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| Authors: | Liu Yuanyuan Lu Meide Zhao Xuejian Wang Zhongshan Zhao Dan |
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| Abstract: | One hundred and twenty-eight Wistar rats were randomly divided into 3 groups: the endotoxic shock (ESG) , panaxadiol saponin pretreated (ESPG) and the control (CG) . Contents of 5-HT in serum and tissues 3,8 and 16 h after injection were determined. Contents of 5-HT in serum and tissues in the ESPG were lower than those in the ESG. These results suggested that panaxadiol saponiu could prevent 5 -HT from being released or enhance its disintegration. Therefore, it could relieve pulmonary hypertension and improve microcirculation. |
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| Keywords: | Endotoxic shock Panaxadiol saponin 5-HT |
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