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| 侧脑室注射6-OHDA对寒冷应激诱导的大鼠血浆ACTH含量的改变 | |
| 引用本文： | 朱永进,龚珊,蒋星红,郭试瑜,久光正. 侧脑室注射6-OHDA对寒冷应激诱导的大鼠血浆ACTH含量的改变[J]. 中国血液流变学杂志, 2003, 13(4): 331-333 |
| 作者姓名： | 朱永进 龚珊 蒋星红 郭试瑜 久光正 |
| 作者单位： | 1. 苏州大学医学院生理教研室,神经生物学研究室,苏州,215007 2. 日本昭和大学医学部第一生理学教室 |
| 摘 要： | 目的 观察侧脑室注射 6 OHDA对 4℃寒冷应激诱导的血浆ACTH含量的改变。方法 成年Wistar雄性大鼠 3 0只 ,随机分成 5组 (n =6) ,分别为空白对照组、寒冷应激组、6 羟基多巴胺 (6 OHDA)非应激组、6 OHDA +寒冷应激组、配药液 +寒冷应激组。所有动物处理后立即取静脉血用放射免疫法测定其血浆ACTH含量。结果 4℃寒冷应激 4h后血浆ACTH含量明显升高 ,与正常对照组相比有明显差异 (P <0 .0 1) :6 OHDA侧脑室注射后再寒冷应激 ,血浆ACTH含量不再明显升高。结论 寒冷应激可能通过脑内儿茶酚胺能系统调控HPA轴的活性 |
| 关 键 词： | 侧脑室注射 6-OHDA 寒冷应激 诱导 大鼠 血浆 ACTH 含量 |
| 文章编号： | 1009-881X(2003)04-0331-03 |
| 修稿时间： | 2003-07-21 |
Changes of Plasma ACTH Level in Rats Induced by Cold Stress after Intracerebroventricular(i.c.v)6-OHDA |
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| ZHU Yong-jin ,GONG Shan ,JIANG Xing-hong ,GUO Shi-yu ,Tadashi Hisamitsu. Changes of Plasma ACTH Level in Rats Induced by Cold Stress after Intracerebroventricular(i.c.v)6-OHDA[J]. Chinese Journal of Hemorheology, 2003, 13(4): 331-333 | |
| Authors: | ZHU Yong-jin GONG Shan JIANG Xing-hong GUO Shi-yu Tadashi Hisamitsu |
| Affiliation: | ZHU Yong-jin 1,GONG Shan 1,JIANG Xing-hong 1,GUO Shi-yu 1,Tadashi Hisamitsu 2 |
| Abstract: | Objective To observe the changes of plasma ACTH level in rats induced by cold stress after i.c.v 6- OHDA Methods The animals we used in this study are adult, male Wistar rats.divided into 5 groups(n=6):control,cold stresa,i.c.v 6-OHDA,i.c.v 6-OHDA+cold stress,i .c.v saline+cold stress.Plasma ACTH was measured by radioimmunoassay.Re sults Plasma ACTH level was increased significantly by cold stress, and this changes could be blocked after 6-OHDA i.c.v.administration.Co nclusion Cold stress may activate HPA axis via catecholaminergic system . |
| Keywords: | old stress 6-OHDA i.c.v ACTH RIA |
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