Synthesis and potent antimicrobial activities of some novel retinoidal monocationic benzimidazoles |
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| Authors: | Ates-Alagöz Zeynep Alp Mehmet Kus Canan Yildiz Sulhiye Buyukbingöl Erdem Göker Hakan |
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| Affiliation: | Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey. |
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| Abstract: | ![]()
Several 2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1H-benzimidazole-5-carboxamidine analogues were synthesized for their antibacterial and antifungal activities against S. aureus, Methicillin-resistant S. aureus (MRSA), C. albicans, and C. krusei. MIC values of the targeted compounds 43-58 are comparable to those of Fluconazole and Sultamicillin. The most potent compounds, 51 and 53, showed MIC values as 0.78 and 1.56 microg/mL against S. aureus and C. albicans, respectively. |
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| Keywords: | Retinoid skeleton Benzimidazole carboxamidines Antibacterial Antifungal activities |
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