不同年龄段成年人群实施结肠镜检查的镇静特点

目的:探讨不同年龄段成年人群中实施镇静性结肠镜检查时的镇静特点,为临床合理用药提供参考.方法:收集180例接受镇静性结肠镜检查的患者,分为青年组(n=45,18～44岁)、壮年组(n=78,45～64岁),老年组(n=57,65～80岁).术前均给予咪唑安定0.02～0.03 mg/kg,异丙酚0.5～2.5 mg/k...

Influence of age on sedation for colonoscopy in adults

ObjectiveTo investigate the efficacy and risk of midazolam and propofol for sedation during colonoscopy procedures in adults of different age groups. MethodsA total of 180 patients undergoing colonoscopy were allocated to 3 groups: a young adult group (n=45，18-44 years), a mid-aged group (n=78，45-64 years) and an elderly group (n=57， 65-80 years). All patients were premedicated with midazolam 0.02-0.03 mg/kg and propofol 0.5-2.5 mg/kg. The pulse rate, arterial pressure, and oxygen saturation for each patient were monitored continuously before, during and after the procedure. ResultsThe doses of midazolam and propofol for the young adults were significantly higher than that for the mid-aged and the eldery （P＜0.01）. Based on the view of gastroenterologists, the satisfied rate of sedation quality was significantly higher in the elderly group than that in the young or the mid-aged group （P＜0.01）. There were significant changes in the arterial pressure in all groups compared with the baseline level （P＜0.01）, but there was no significant difference among the 3 groups. Other parameters such as heart rate, saturation of O2, and the rate of severe adverse reaction among the 3 groups were not significantly different （P＞0.05）. ConclusionHigher dose of midazolam and propofol is needed to obtain the sedation quality in young adults. Whereas for the elderly, properly reducing the dose of midazolam and propofol may still keep the sedation quality during colonoscopy procedures.