|
|||||
|
|
| 雷公藤多甙治疗家兔实验性肾小球肾炎 | |
| 引用本文： | 吴志英 宋家栋. 雷公藤多甙治疗家兔实验性肾小球肾炎[J]. 上海交通大学学报(医学版), 1990, 10(1): 6-11 |
| 作者姓名： | 吴志英 宋家栋 |
| 作者单位： | 上海第二医科大学附属仁济医院肾病研究室(吴志英,史家栋,张介玉),上海第二医科大学附属仁济医院肾病研究室(张庆怡) |
| 摘 要： | 采用原位免疫复体动物模型,按15mg/kg雷公藤多甙服用四周,尿蛋白明显下降,盘状蛋白电泳从大分子转向中分子蛋白,血浆蛋白、肌酐均恢复正常。病理检查示治疗组肾小球大小与细胞数均明显小于对照组,IgG,C3,BSA~+及带负电荷辣根过氧化酶在肾小球中沉积不明显。作者对雷公藤多甙作用机理作了讨论。 |
| 关 键 词： | 肾小球肾炎 雷公藤多甙 家兔 |
Treatment of Experimental Glomerulonephritis in Rabbits by Tripterygium Wilfordii Polyglycosidium |
|
| Wu Zhiying,et al Research Secton of Kidney Diseases,Renji Hospital,Shanghai Second Medical University,Shanghai. Treatment of Experimental Glomerulonephritis in Rabbits by Tripterygium Wilfordii Polyglycosidium[J]. Journal of Shanghai Jiaotong University:Medical Science, 1990, 10(1): 6-11 | |
| Authors: | Wu Zhiying et al Research Secton of Kidney Diseases Renji Hospital Shanghai Second Medical University Shanghai |
| Abstract: | Twenty rabbits as animal model with in situ immune complex were given "tripterygium wilfordii polyglycosidium" (15/kg) for four weeks. The proteinuria decreased more sharply than before (P<0.025). SDS-PAGE test showed a change of proteinuria from the macromolecular into mederatemolecular. At the same time, serum albumin and endogenous creatinine clearance returned to normal. In histopathology, light microscope showed that the diameter and quantity of glomerular cells in treated animals were obviously smaller that the control animals (P<0.05, 0.01 respectively). Immunofluorescent staining revealed light positive reaction. Electromicroscopy revealed no obvious election-dense deposits in glomeruli. The effect and mechanism of TWP were discussed. |
| Keywords: | tripterygium wilfordii polycosidium situ immune complex cationic bovine serum albumin |
| 本文献已被 CNKI 维普 等数据库收录！ | |