胆汁反流性胃炎临床治疗分析

目的：探讨多潘立酮（吗丁啉）和铝碳酸镁联合用药治疗胆汁反流性胃炎的临床疗效。方法：将我科2006年2月-2009年6月收治的148例胆汁反流性胃炎患者随机分为治疗组和对照组，各74例。治疗组74例，口服多潘立酮片10mg，3次／d，餐前15min服药，铝碳酸镁0．5g,3次／d，餐后1h服用，治疗4周。对照组74例，口服铝碳酸镁0.5g，3，次/d，餐后1h服用，治疗4周。分别于治疗前及治疗4周后记录上腹痛、饱胀、恶心、呕吐症状的积分，予以对比观察，疗程结束后复查胃镜。结果：治疗组临床疗效总有效率为94．6％，对照组总有效率为78．3％；胃镜征象疗效分别为89．2％、70．3％。治疗后两组患者的症状均有减轻，治疗组减轻明显优于对照组。结论：多潘立酮可减少胃内胆汁反流，铝碳酸镁可结合胆酸，两者联合用药治疗胆汁反流性胃炎疗效显著，值得推广应用。

Clinical analysis in the treatment of bile-reflux gastritis

Objective： To explore the clinical efficacy of domperidone （Motilium） combined with aluminum magnesium carbonate in the treatment of bile reflux gastritis. Methods： 148 cases of patients with bile reflux gastritis from February 2006 to June 2009 in Qur department were randomly divided into treatment group （74 cases） and control group（74 cases）. The treatment ,group （74 cases）, domperidone tablets 10 mg, oral 3 times/day, fasting for 15 minutes on medication, aluminum magnesium carbonate 0.5 g, 3 times/day, taken one hour after the meal. treatment for 4 weeks. In the control group, 74 cases of oral aluminum magnesium carbonate 0.5 g, 3 times/day, taken one hour after the meal. treatment for 4 weeks, Respectively, before treatment and treatment for 4 weeks after the record of abdominal pain. fullness, nausea, vomiting, symptoms of points to be： comparative study, after the review of endoscopic treatment. Results： The clinical efficacy of the treatment group, the total effective rate was 94.6%, the total effective rate of the control group was 78.3%. endoscopic signs of efficacy were 89.2%, 70.3%. After treatment of patients with symptoms of both groups were reduced significantly, but the treatment group was better than the control group. Conclusion： Domperidone can be reduced intragastric bile reflux, aluminum magnesium carbonate can be combined acid. both of combination therapy in treating bile reflux gastritis is significant, and to be worthy of promotion.